New Yorkers give NJ's Christie highest marks for storm response

NEW YORK (Reuters) - New York-area politicians won high marks from the city's residents for their response to superstorm Sandy, but it was New Jersey's Republican Governor Chris Christie who most impressed New Yorkers, a Quinnipiac University poll said on Tuesday.

Nearly 90 percent of New York City voters rated Christie's response to the storm, which left large swaths of the region without power and cut off from mass transit and devastated the New Jersey shoreline, as "excellent" or "good."

Christie offered strong praise for Obama's storm response in the days after Sandy. Because the poll only surveyed New York City voters, there was no input from Christie's New Jersey constituents.

More than a third of voters in Democratic-leaning New York said Christie, a Republican star, did the "best job" handling the storm. Nearly a quarter of voters gave that title to Obama.

New York Governor Andrew Cuomo, a Democrat, got high marks from 85 percent of voters. Mayor Michael Bloomberg, an independent, was rated as having done an "excellent" or "good" job by 75 percent of voters.

"The storm-of-the-century brings out the best in Governor Andrew Cuomo and Mayor Michael Bloomberg, New Yorkers say. But that love fest between ... Christie and ... Obama seems to have moved voters especially," said Quinnipiac spokesman Maurice Carroll.

The Metropolitan Transportation Authority, which runs the city's subway, bus and commuter train services, also received high marks for what was seen as the Herculean feat of emptying flooded tunnels and subway stations and bringing mass transit back on line within a week of the storm.

People were less impressed by the response by utility companies, which include Con Edison and the Long Island Power Authority. More than half of city voters said the companies, which left millions of residents without power for weeks after the storm, had done a "not so good" or "poor" job.

Nearly eight in 10 voters say global climate change will make ferocious storms like Sandy more frequent, a phenomenon that more than six in 10 attribute to burning fossil fuels.

New Yorkers say they are behind the city spending billions of dollars to better protect the city from future storms, especially if it reduces the cost of disruptions.

"If the preventive measures cost billions, New Yorkers say, let's spend it," Carroll said.

The survey of 1,165 New York City voters was conducted from November 14 to 18 over land lines and cell telephones and had a margin of error of plus or minus 2.9 percentage points.

(Reporting by Edith Honan, Editing by Ellen Wulfhorst and Cynthia Osterman)

Source: http://news.yahoo.com/yorkers-njs-christie-highest-marks-storm-response-181358149.html

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HISTPRES + Director of Development, Pleasant Retreat: The ...

We are seeking an energetic, extroverted, business-minded Director of Development to promote Pleasant Retreat, and develop & manage an operating budget. Living quarters are provided (including utilities) on museum property.

Job Responsibilities

Duties:

• Advertise
• Advocate
• Fundraise
• Grant Writing
• Development
• Plan/Execute Events
• Community Outreach
• Nurture Museum Membership

Qualifications

Qualifications:

• Strong public speaking skills and excellent ability to write persuasively.
• Confident budgeting and financial analysis skills.
• Proven success in event planning.
• Strong computer skills.
• Time management skills.
• Independent worker.

Education:

• Must hold a Bachelors degree in Philanthropic Studies, Marketing, Business, Nonprofit Management or related degree.
• Trained in raising funds for nonprofit organizations.

About the Company/Organization

Pleasant Retreat: The Governor William Owsley House Museum is seeking a Director of Development. The Governor William Owsley House, Pleasant Retreat, was saved from demolition in 1993. The State of Kentucky, dedicated Garrard County citizens, and faithful Owsley family descendants restored the historic landmark. This young museum is owned by Garrard County and under the direction of a board of trustees.

We are seeking an energetic, extroverted, business-minded Director of Development to promote Pleasant Retreat and develop and manage an operating budget. Living quarters are provided (including utilities) on museum property.

Salary or Pay Rate

Self-Generated. Living quarters are provided (including utilities).

How To Apply

To Apply, send Cover Letter and Resume to:

Travis Rose
656 Stanford Road
Lancaster, KY 40444

Or email attachments of the above to director@owsleyhouse.org.
Deadline: November 30, 2012 (or until filled)

Additional Information

This position will be focused on raising funds and creating revenue. All preservation/conservation is managed by a museum curator.

Source: http://histpres.com/director-of-development-pleasant-retreat-the-governor-william-owsley-house-museum-2

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India vs England Live: Cook scores 21st Test century

Alastair Cook and Nick Compton gave England a solid start after Pragyan Ojha?s five-wicket haul forced the visitors to follow on.

England managed just 191 all out in their first innings, but were 111-0 at the start of day four.

Here are live updates of the crucial day in Ahmedabad:

Earlier, India put up a mammoth 521 runs before they declared. Cheteshwar Pujara and Virender Sehwag were both centurions with the former scoring his maiden double-ton with an unbeaten 206. Sehwag scored 117 before he was bowled by Swann.

Reuters

Even in England?s first innings, Cook scored 41, which was second highest to Matt Prior?s 48. But the spinners have always troubled visitors in India, and it?s happening again.

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Source: http://www.firstpost.com/sports/india-vs-england-live-can-captain-cook-save-the-day-527092.html

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Florida officials re-thinking opposition to 'Obamacare'

TALLAHASSEE?

What a difference an election can make.

Just a week after the re-election of Barack Obama ended all Republican hopes of overturning the new health care law known as "Obamacare," Gov. Rick Scott and other Florida leaders who have steadfastly rejected the idea are now willing to at least talk about implementing it for the state's 3.8 million uninsured.

"Mitt Romney did not win the election," Scott told reporters Friday in Washington D.C., hours before he released a letter to Health and Human Services Secretary Kathleen Sebelius asking for a meeting to discuss implementing the law. "So it's not an option to repeal Obamacare. So my goal now is: focus on what's good for our citizens."

He added: "The official response is going to be: 'I want to sit down with you. I want to see how we can work together to lower health care costs for Floridians.'"

But it will be some time before Florida decides on how to implement crucial elements of the Affordable Care Act: setting up an insurance "exchange" and adding lower-income Floridians to the Medicaid program.

Incoming House Speaker Will Weatherford and Senate President Don Gaetz wrote Sebelius Thursday night saying they could not yet make a call on whether to start an exchange ? essentially, a state-run health insurance marketplace for small businesses and individuals.

The law says that if a state refuses to set up an exchange, the federal government will do it. So far, 13 states ? mostly Democratic ? and the District of Columbia have officially said they will run their own exchanges.

Weatherford and Gaetz wrote that 100 rules and regulations are still being developed by the Obama administration, including guidelines on minimum coverage and benefits. And in his letter Friday, Scott said startup costs "are projected at $92.3 million" through next year, and annual operating costs to the state ? based on experience in Illinois -- could range from $57.4 million to $88.6 million by 2016.

"We should be looking out for our consumers and we should be looking out for our state and doing what's best for them," said Weatherford, R-Wesley Chapel. "The problem is there are hundreds of unanswered questions that are out there with regard to the implementation to the Affordable Health Care Act. Until we have the answers to those questions, we don't know which plan gives our consumers the most choices."

Insurers are researching and trying to develop plans that work with the new requirements, but they too have a lot of questions, said Michael Garner, executive director of the Florida Association of Health Plans, a trade association for health insurers. They haven't even figured out if it's better for the federal government or the state to run the exchanges, or some sort of partnership.

"Until we get more information, it's too difficult to stipulate which direction is best," Garner said.

The federal government counters that states have been offered help in getting the process started, and the deadline to decide on who should run the exchange has been extended from last week to Dec. 14. HHS has provided a blueprint of what a state exchange should look like and offered grants to pay design costs. Florida applied for the money in 2010 under Gov. Charlie Crist, but Scott ordered the state to return the $1 million check.

The exchanges are a crucial key to the health care overhaul, which by 2014 will require all adults to either purchase health insurance, enroll in a federally subsidized plan ? or pay a tax.

Large employers will be required to provide health coverage to employees or pay a fine. Smaller companies, of up to 100 employees, and individuals not covered by an employer would find insurance using the exchange, and lower-income purchasers would qualify for federal subsidies. Plans offered by the exchanges would provide a minimum level of benefits, with limited co-payments and out-of-pocket expenses.

The exchanges must begin enrolling users by October 2013 and be fully operational by Jan. 1, 2014.

Both Weatherford and Gaetz have said they want the Legislature to decide whether the state or federal government should run the insurance exchange, and whether Florida should expand its Medicaid program to cover an estimated 800,000 to 1.3 million low-income individuals who currently earn too much to qualify. In upholding the law in June, the U.S. Supreme Court said states could not be compelled to expand Medicaid eligibility.

Though the feds will pay 100 percent of the cost of the new enrollees, that will drop to 90 percent by 2020. Scott has said the state can't afford the expansion of Medicaid, which state analysts have pegged at about $1 billion but which Scott insists is likely to be higher.

Scott also is seeking federal approval to put the state's existing Medicaid patients into managed care ? like HMOs ? under a cost-cutting proposal passed by the 2011 Legislature. "Statewide Medicaid managed care is one way we can act immediately to encourage more competition in health care which would drive down costs and increase outcomes and services,'' he wrote in his letter to Sebelius.

Gaetz said he and Weatherford have asked legislative staff to engage with HHS staffers about what their options are.

"It's a law, and it's a constitutional law," Gaetz said. "There's a ruling on the question. It is my constitutional duty to implement the law, and I will do it."

One option the Florida Legislature will look at is converting Florida Healthy Choices or Florida Healthy Kids into an insurance exchange that meets the health care act's requirements.

Florida Healthy Kids, which was created in 1990, has covered more than 1 million low-income children from families who don't qualify for Medicaid. Most families pay nothing for the insurance.

Florida Health Choices, created by the Legislature in 2008, is an online marketplace of insurance plans that will function like an exchange ? but without the minimum benefit requirement. Rose Naff, chief executive officer of the group, said she hopes to be fully operational this spring.

When its website opens, Florida Health Choices will allow employers to enter where the company is based, the number of employees and the birth dates of all its employees. The site will generate a list of available insurance plans, showing monthly premiums as well as deductibles, copays and other benefits.

Staff Writers William Gibson and Aaron Deslatte contributed to this report.

khaughney@tribune.com or 85-224-6214

Source: http://www.sun-sentinel.com/fl-scott-state-working-on-healthcare-compromise-20121118,0,454194.story?track=rss

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How eating meat, cooking made us human

Vegetarian, vegan and raw diets can be healthy ? likely far healthier than the typical American diet. But to continue to call these diets "natural" for humans, in terms of evolution, is a bit of a stretch, according to two recent, independent studies.

Eating meat and cooking food made us human, the studies suggest, enabling the brains of our prehuman ancestors to grow dramatically over a period of a few million years.

Although this isn't the first such assertion from archaeologists and evolutionary biologists, the new studies demonstrate, respectively, that it would have been biologically implausible for humans to evolve such a large brain on a raw, vegan diet and that meat-eating was a crucial element of human evolution at least 1 million years before the dawn of humankind.

Shhh, don't tell the gorillas
At the core of this research is the understanding that the modern human brain consumes 20 percent of the body's energy at rest, twice that of other primates. Meat and cooked foods were needed to provide the necessary calorie boost to feed a growing brain. [ 10 Things You Didn't Know About the Human Brain ]

One study, published last month in the journal Proceedings of the National Academy of Sciences, examined the brain sizes of several primates. For the most part, larger bodies have larger brains across species. Yet humans have exceptionally large, neuron-rich brains for our body size, while gorillas ? three times more massive than humans ? have smaller brains and three times fewer neurons. Why?

The answer, it seems, is the gorillas' raw, vegan diet (devoid of animal protein), which requires hours upon hours of eating only plants to provide enough calories to support their mass.

Researchers from Brazil, led by Suzana Herculano-Houzel, a neuroscientist at the Federal University of Rio de Janeiro in Brazil, calculated that adding neurons to the primate brain comes at a fixed cost of approximately six calories per billion neurons.

For gorillas to evolve a humanlike brain, they would need an additional 733 calories a day, which would require another two hours of feeding, the authors wrote. A gorilla already spends as much as 80 percent of the tropic's 12 hours of daylight eating.

Similarly, early humans eating only raw vegetation would have needed to munch for more than nine hours a day to consume enough calories, the researchers calculated. Thus, a raw, vegan diet would have been unlikely given the danger and other difficulties of gathering so much food.

Cooking makes more foods edible year-round and releases more nutrients and calories from both vegetables and meat, Herculano-Houzel said.

"The bottom line is, it is certainly possible to survive on an exclusively raw diet in our modern day, but it was most likely impossible to survive on an exclusively raw diet when our species appeared," Herculano-Houzel told LiveScience.

1. Science news from NBCNews.com

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The study puts an upper limit on how big a brain is able to grow while on a premodern raw, vegan diet. But the researchers could not determine when daily cooking began. Was it about 250,000 years ago, when humans were nearly fully evolved with big brains, which is supported by archaeological findings; or was it about 800,000 years ago, when prehumans began their most dramatic brain-growth spurt, an era for which there is little archaeological evidence of controlled fires for cooking?

Meet the meat-eater
If cooking wasn't routine in the years before the dawn of modern humans, eating meat certainly was.

The second study, published in October the journal PLoS ONE, examined the remains of a prehuman toddler who died from malnutrition about 1.5 million years ago. Shards of a skull found in modern-day Tanzania reveal that the child had porotic hyperostosis, a type of spongy bone growth associated with low levels of dietary iron and vitamins B9 and B12, the result of diet lacking animal products in a species that requires them. [ 10 Mysteries of the First Humans ]

The child was around the weaning age. So, either the child's mother's breast milk lacked key nutrients, or the child himself did not consume enough nutrients directly from meat or eggs.

Either way, the finding implies that meat must have been an integral, and not sporadic, element of the prehuman diet more than 1 million years ago, said the study's lead author, Manuel Dom?nguez-Rodrigo, an archaeologist at Complutense University in Madrid.

This supports the theory that meat fueled human brain evolution because meat ? from arachnids to zebras ? was plentiful on the African savanna, where humans evolved, and is the best package of calories, proteins, fats and vitamin B12 needed for brain growth and maintenance.

"Carnivore animals, whether terrestrial or aquatic, are bigger brained than herbivores," Dom?nguez-Rodrigo told LiveScience. And he added that "there is no [traditional] society that live as vegans," essentially because it wouldn't be possible to get vitamin B12, which is only available in animal products.

Vegetables still healthy
Both sets of researchers said their conclusion ? that cooked food and meat were necessary for human brain development ? is not a statement of how the human diet must have been, but rather how it likely was in order to make humans "human."

With supermarkets and refrigeration, humans today can and increasingly do eat a vegetarian or vegan diet year-round. And given the amount of heart-stopping saturated fats in factory-produced animal products, a plant-based diet can be healthier.

Yet both "extreme sides" of the meat argument ? the unapologetic meat eater and the raw vegan ? should remember that few so-called natural foods today were around as little as a few hundred years ago, from the modern invention called corn-fed beef to genetically altered strains of Queen Anne's lace called the carrot.

From health to the environment, there are many reasons to go vegetarian, go vegan and even go raw, but evolution isn't one of them.

Christopher Wanjek is the author of a new novel, " Hey, Einstein! ", a comical nature-versus-nurture tale about raising clones of Albert Einstein in less-than-ideal settings. His column, Bad Medicine, appears regularly on LiveScience.

? 2012 LiveScience.com. All rights reserved.

Source: http://www.msnbc.msn.com/id/49888012/ns/technology_and_science-science/

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The magically disappearing copyright report | PWxyz

When I was working in the Open Book Alliance to defeat the Google Book Search proposals, one of the first things that I learned as a neophyte working the Hill was that one?s allies and foes on legislative action swirled in fluid kaleidoscopes. Coalitions formed and then re-formed depending on what was at issue, and who had a stake. Public positions could change suddenly and inexplicably, until one figured out whom had spoken to who.

So it was this weekend before Thanksgiving. On Friday, 16 November, the conservative Republican Study Committee (RSC) released an amazingly liberal document proposing deep and substantive reforms in U.S. copyright law. Within 24 hours, on Saturday, 17 November, the report had been pulled from the House website and an email apology for its ?inadequate? vetting had been flung out on the net. Hollywood had hit their phones, and the political volte-face was as dramatic as something out of Hitchcock?s The Man Who Knew Too Much.

The RSC channels much of the House of Representatives Republican Conference, orienting the Party leadership towards conservative proposals. The copyright report, ?Three Myths about Copyright Law and Where to Start to Fix it,? was initially posted at the web site of the current RSC chairman, Jim Jordan. It highlighted fundamental copyright flaws and suggested reforms which, save for a few infeasible proposals, could have come out of liberal west coast centers of copyright scholarship. It was authored by a young staffer, Derek Khanna, and the study paper demonstrates the growing generational rift in the understanding of business reliance on networked technologies.

The report notes the original intent of the Copyright Act to promote the progress of science and the useful arts, and then observes that ?most legislative discussions on this topic, particularly during the extension of the copyright term, are not premised upon what is in the public good or what will promote the most productivity and innovation, but rather what the content creators ?deserve? or are ?entitled to? by virtue of their creation,? and goes on to suggest that ?because of the constitutional basis of copyright and patent, legislative discussions on copyright/patent reform should be based upon what promotes the maximum ?progress of sciences and useful arts? instead of ?deserving? financial compensation? [emphasis in the original].

The RSC report?s presumption is that government has overreached by legislating copyright too aggressively, overtly interfering with the free market and hindering innovation. ?Today?s legal regime of copyright law is seen by many as a form of corporate welfare that hurts innovation and hurts the consumer. It is a system that picks winners and losers, and the losers are new industries that could generate new wealth and added value.? The report notes the deleterious impact on remix culture, on the sharing of scientific inquiry and knowledge, and the inability to establish a comprehensive digital library of 20th Century materials. Its authors protest that ?still today an enormous amount of intellectual knowledge in locked behind physical books, rather than accessible on the general internet. ? Imagine the potential for greater learning as a result of obtaining books from the 1920-1980 periods.?

The report details four areas of potential reform: 1). Statutory Damages. ?Copyright awards were meant to make the copyright holder whole ? they were not supposed to be punitive. Reforming this process is an important element of federal tort reform, which unlike other forms of tort reform is clearly within the federal prerogative.? 2). Expansion of Fair Use. ?Right now, it?s somewhat arbitrary as to what is legally fair use based upon judicially created categories.? 3). Punish false copyright claims. ?Because there is minimal or nearly non-existent punishment for bogus copyright claims today, false takedown requests are common and have a chilling effect upon legitimate speech.? And, 4). Limit copyright terms and create disincentives for renewal. The report elucidates one possible path, with an initial 12 year copyright award period and renewable elective terms that are fee-based, with a maximum cliff of 46 years protection. This last proposal is actually currently infeasible in an international context, which is based on life of the author plus 50 years (life+50) for most non-corporate works.

It is a stunning document, and it wasn?t destined to last. Reporter Mike Masnick at TechDirt intimates that RIAA and MPAA hit the phones, but whoever did, they were loud and persuasive. By Saturday evening, the report was gone from the House web, and Paul Teller, the current executive director, sent out a startling note of retraction:

From: Teller, Paul
Sent: Saturday, November 17, 2012 04:11 PM
Subject: RSC Copyright PB

We at the RSC take pride in providing informative analysis of major policy issues and pending legislation that accounts for the range of perspectives held by RSC Members and within the conservative community. Yesterday you received a Policy Brief on copyright law that was published without adequate review within the RSC and failed to meet that standard. Copyright reform would have far-reaching impacts, so it is incredibly important that it be approached with all facts and viewpoints in hand. As the RSC?s Executive Director, I apologize and take full responsibility for this oversight. Enjoy the rest of your weekend and a meaningful Thanksgiving holiday?.

Paul S. Teller
Executive Director
U.S. House Republican Study Committee
Paul.Teller@mail.house.gov
http://republicanstudycommittee.com

The RSC report on copyright reform was a clear-headed and hard look at the dysfunctions in the copyright system, and equally clearly some very powerful people didn?t like it. The American people deserve better than this: if the Republican Study Committee is smart enough to recognize that legislative action is necessary to spur progress of sciences and the useful arts, then we deserve a public hearing on how to adapt that goal to a digital age without excessive interference from Hollywood lobbyists. Real leadership ? whether from the Republican or the Democratic parties ? requires facing down influence to drive a hard discussion of the truth. We?re still waiting, but this weekend, we got a glimpse of what honesty looks like.

Source: http://blogs.publishersweekly.com/blogs/PWxyz/2012/11/18/magically-disappearing-copyright-report/

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Wisconsin Energy Institute Town Hall

• Date Monday, Nov. 19, 2012
• Time 2 p.m.
• LocationH.F. DeLuca Forum, Wisconsin Institutes for Discovery
• DescriptionThe Wisconsin Energy Institute will be the catalytic home of energy research at UW-Madison, bringing together researchers from multiple disciplines to develop innovative solutions for energy challenges. Join us to learn about cross-campus collaborative opportunities through the Institute.
• CostFree
• Contact890-3682, sbanks@glbrc.wisc.edu
• Tagged under

Add this event to your calendar: iCalendar Email Invite

Source: http://www.today.wisc.edu/events/view/57096

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US pushing 'jobs diplomacy' after costly wars: Clinton

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Source: http://news.ph.msn.com/business/article.aspx?cp-documentid=251156312

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PlayStation 3 global sales hit 70 million, over 15 million Move controllers sold

Sony has announced that it's now sold over 70 million PlayStation 3 consoles -- matching the number of Xboxes sold according to Microsoft's latest financial report. Direct from the Japanese console maker, it also revealed that more than 15 million PlayStation Move motion controllers have been sold since its launch over two years ago. Meanwhile, the slightly aging (but constantly tweaked) base console is now approaching its sixth birthday, but there's no word yet on its hardware successor, with Sony preferring to focus on new connectivity features between the PS3 and its handheld relative.

Continue reading PlayStation 3 global sales hit 70 million, over 15 million Move controllers sold

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PlayStation 3 global sales hit 70 million, over 15 million Move controllers sold originally appeared on Engadget on Fri, 16 Nov 2012 03:44:00 EDT. Please see our terms for use of feeds.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/syeEhY1tIPQ/

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Cutting-edge approaches to ensuring biologic drug quality focus of forum on bioassays

Public release date: 16-Nov-2012
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Contact: Theresa Laranang-Mutlu
trl@usp.org
301-816-8167
US Pharmacopeia

Rockville, Md., November 16, 2012 As a growing number of biologic drugs are treatments of choice for an expanding list of autoimmune disorders, inflammatory diseases, and certain cancers, bioassays play a critical role in establishing the functional integrity and potency of these products. Hosted by the United States Pharmacopeial Convention (USP), the Fifth Bioassay Workshop will take place on December 4-5, 2012, at USP's headquarters in Rockville, Md. The workshop will focus on the development, monitoring and validation/revalidation of bioassays. It will feature perspectives from manufacturers, regulators and other stakeholders on such topics as the replacement of animal-based assays with cell-based assays; USP's standards for bioassays; software selection for bioassay development and other related topics.

According to Roger L. Williams, M.D., chief executive officer of USP, "Developing standards for modern medicines such as biologics is a complicated yet important undertaking. Through forums like USP's Fifth Bioassay Workshop, manufacturers, regulators and other stakeholders can exchange ideas and strategies for approaching important issues such as bioassay development. Being able to share information and expertise undergirds our ability to create standards that help to ensure the quality of the global drug supply."

Conventional pharmaceuticals are made through chemical routes and have small molecular structures. Biologicsparticularly more modern ones such as recombinant proteins and monoclonal antibodiesare larger and more complex in their makeup, and are derived from living cells or organisms. As a result, it is not possible to fully characterize biologic drugs in the same way that chemical drugs are characterized using commonly-applied analytical techniques and procedures. Bioassays are used to assign or confirm drug potency and to validate that a drug is functioning as expected, usually by comparison to a known reference standard. Since manufacturing processes for biologics are continuously changing throughout the development and life cycle of a biologic drug, bioassays are important for maintaining the integrity of a drug's potency and for determining that the drug is continuing to work in the manner in which it is intended.

Cell-based assays will be one of the topics discussed at the USP Bioassay Workshop. USP's current activities in this area include standards development for biological medicines involving cell-based assays to measure erythropoietin bioactivity and somatropin cell-based bioidentity methods. Emerging technologies are making it possible for manufacturers to consider novel methods for measuring a drug's potency. Compared to traditional animal-based testing, some newer cell-based assays are enabling more precise measurements of potency and drug activity and are proving to be easier to execute in the laboratory. However, manufacturers must be able to demonstrate that newer, cell-based assays are suitable replacements for older methods based on clinical and safety data obtained using previous assays and clinical trial batches of the drug. Regulatory perspectives on the implementation of new methods will also be discussed.

In August 2012, a suite of standards known as the "USP Bioassay Chapters" became official in USP's published compendia of standardsUnited States Pharmacopeia and the National Formulary (USPNF). The December workshop will feature a session dedicated to the USP Bioassay Chapters and will include presentations on user feedback regarding their applicability to bioassay development and validation during drug development and post-licensure stages. Perspectives on bioassay challenges from the U.S. Food and Drug Administration (FDA) also will be featured during this session.

While great emphasis is placed on validation and use of bioassay methods, the qualification of critical reagents and references materials used during the life cycle of a product also is very important. Strategies for monitoring and replacing these materials will be highlighted during the workshop.

The workshop also will provide attendees with a unique opportunity to interact with vendors of bioassay development software. In addition to an open-forum Q&A session with software vendors, one-on-one discussion sessions with vendors will allow users to elaborate on their own in-house needs and determine how specific software offerings can address them.

Registration is available at a rate of $950 for industry and $500 for association/government/academia. Group discounts are also available. For information on USP's Pharmacopeial Education course on USP's Bioassay Chapters on December 3, 2012, click here. For information about the workshop, go to: http://uspgo.to/bioassay-workshop. Hear from one of USP's Expert Committee members about the workshop by clicking http://uspgo.to/UF8Jle.

###

Reporters interested in attending this event may register free-of-charge by contacting Theresa Laranang-Mutlu at trl@usp.org.

USP Advancing Public Health Since 1820

The United States Pharmacopeial Convention (USP) is a scientific, nonprofit, standards-setting organization that advances public health through public standards and related programs that help ensure the quality, safety, and benefit of medicines and foods. USP's standards are relied upon and used worldwide. For more information about USP visit http://www.usp.org.

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Public release date: 16-Nov-2012
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Contact: Theresa Laranang-Mutlu
trl@usp.org
301-816-8167
US Pharmacopeia

Rockville, Md., November 16, 2012 As a growing number of biologic drugs are treatments of choice for an expanding list of autoimmune disorders, inflammatory diseases, and certain cancers, bioassays play a critical role in establishing the functional integrity and potency of these products. Hosted by the United States Pharmacopeial Convention (USP), the Fifth Bioassay Workshop will take place on December 4-5, 2012, at USP's headquarters in Rockville, Md. The workshop will focus on the development, monitoring and validation/revalidation of bioassays. It will feature perspectives from manufacturers, regulators and other stakeholders on such topics as the replacement of animal-based assays with cell-based assays; USP's standards for bioassays; software selection for bioassay development and other related topics.

According to Roger L. Williams, M.D., chief executive officer of USP, "Developing standards for modern medicines such as biologics is a complicated yet important undertaking. Through forums like USP's Fifth Bioassay Workshop, manufacturers, regulators and other stakeholders can exchange ideas and strategies for approaching important issues such as bioassay development. Being able to share information and expertise undergirds our ability to create standards that help to ensure the quality of the global drug supply."

Conventional pharmaceuticals are made through chemical routes and have small molecular structures. Biologicsparticularly more modern ones such as recombinant proteins and monoclonal antibodiesare larger and more complex in their makeup, and are derived from living cells or organisms. As a result, it is not possible to fully characterize biologic drugs in the same way that chemical drugs are characterized using commonly-applied analytical techniques and procedures. Bioassays are used to assign or confirm drug potency and to validate that a drug is functioning as expected, usually by comparison to a known reference standard. Since manufacturing processes for biologics are continuously changing throughout the development and life cycle of a biologic drug, bioassays are important for maintaining the integrity of a drug's potency and for determining that the drug is continuing to work in the manner in which it is intended.

Cell-based assays will be one of the topics discussed at the USP Bioassay Workshop. USP's current activities in this area include standards development for biological medicines involving cell-based assays to measure erythropoietin bioactivity and somatropin cell-based bioidentity methods. Emerging technologies are making it possible for manufacturers to consider novel methods for measuring a drug's potency. Compared to traditional animal-based testing, some newer cell-based assays are enabling more precise measurements of potency and drug activity and are proving to be easier to execute in the laboratory. However, manufacturers must be able to demonstrate that newer, cell-based assays are suitable replacements for older methods based on clinical and safety data obtained using previous assays and clinical trial batches of the drug. Regulatory perspectives on the implementation of new methods will also be discussed.

In August 2012, a suite of standards known as the "USP Bioassay Chapters" became official in USP's published compendia of standardsUnited States Pharmacopeia and the National Formulary (USPNF). The December workshop will feature a session dedicated to the USP Bioassay Chapters and will include presentations on user feedback regarding their applicability to bioassay development and validation during drug development and post-licensure stages. Perspectives on bioassay challenges from the U.S. Food and Drug Administration (FDA) also will be featured during this session.

While great emphasis is placed on validation and use of bioassay methods, the qualification of critical reagents and references materials used during the life cycle of a product also is very important. Strategies for monitoring and replacing these materials will be highlighted during the workshop.

The workshop also will provide attendees with a unique opportunity to interact with vendors of bioassay development software. In addition to an open-forum Q&A session with software vendors, one-on-one discussion sessions with vendors will allow users to elaborate on their own in-house needs and determine how specific software offerings can address them.

Registration is available at a rate of $950 for industry and $500 for association/government/academia. Group discounts are also available. For information on USP's Pharmacopeial Education course on USP's Bioassay Chapters on December 3, 2012, click here. For information about the workshop, go to: http://uspgo.to/bioassay-workshop. Hear from one of USP's Expert Committee members about the workshop by clicking http://uspgo.to/UF8Jle.

###

Reporters interested in attending this event may register free-of-charge by contacting Theresa Laranang-Mutlu at trl@usp.org.

USP Advancing Public Health Since 1820

The United States Pharmacopeial Convention (USP) is a scientific, nonprofit, standards-setting organization that advances public health through public standards and related programs that help ensure the quality, safety, and benefit of medicines and foods. USP's standards are relied upon and used worldwide. For more information about USP visit http://www.usp.org.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-11/up-cat111612.php

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Indonesian Themed Adventure Game Wanara is Out on Android

Indonesian digital art studio Mechanimotion Entertainment and game developer Elven Games released the first episode of an Indonesian folklore-themed gaming app for Android called The Adventure of Wanara: Garuda Riders this week. Interestingly, the game takes the form of an interactive comic. We talked with Mahdi Bashroni Rizal, the CEO of Elven Games, about his latest game.

The Adventures of Wanara tells the story of protagonist Naradja, who is a descendant of three races: human (Rama), giant (Rahwana), and monkey (Hanoman). Naradja will have to stop the resurrection of the devil king from inside him by collecting the eight God elements or Hastabrata. The app is loaded with mini games, animation, and Bali-themed background music to help get the fun going.

Mahdi said that the game story was inspired by the Indonesian folk tale Ramayana. The team wanted to create a unique experience where people not only can have the pleasure of reading the comic books? story, but also feel more involved as well with the app?s aforementioned features.

Garuda Riders is only the first out of the five episodes for The Adventure of Wanara. Its sequel, Eye of Garuda, will be released next month. The games? development is sponsored by Indonesian telco operator Telkom.

Elven Games has built other Indonesian-themed games previously such as Durian?s Revenge and Nusantara Chronicle. Mahdi explained that it is indeed their mission to showcase the Indonesian culture through gaming media to the international community. He cited Japan?s success in promoting its culture globally through games and anime as a source of inspiration..

By the way, Elven Games is the same game studio whose game Chase Burger was hijacked recently. The company has just changed its name from Elventales Studio to Elven Games now. You can download The Adventure of Nawara here. The iOS version of the game will be available soon.

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About Enricko Lukman

Enricko is a big fan of entrepreneurship. He enjoys debating and discussing a broad range of topics from politics to football. He loyally supports Manchester City F.C., enjoys traveling, and playing video games. For news tips, startup pitches, or feedback, this is his email.

Source: http://feedproxy.google.com/~r/PennOlson/~3/183xg0Qu1Co/

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20. Sony tumbles on convertible bonds issue

TOKYO: Shares of Sony Corp tumbled over 10%, a day after the consumer electronics maker said it will raise 150 billion yen (US$1.9bil) through a sale of convertible bonds to help finance a series of investments.

Sony, beset with falling demand in its core TV business and the growth of rivals like Apple Inc and Samsung Electronics Co, has invested in an assortment of businesses from medical equipment to cloud gaming after CEO Kazuo Hirai took the helm in April.

On Wednesday, the maker of Vaio laptops and PlayStation game consoles said it would issue the five-year bonds convertible into shares to finance an investment in Olympus Corp, the acquisition of US firm Gaikai Inc, ramping up in CMOS (complementary metal oxide silicon) image sensors used in devices like digital cameras and to repay debt.

Sony shares plunged 10.7% to 777 yen. If the stock price were to finish the day with such losses, the shares would hit their lowest close since 1980, according to Thomson Reuters Datastream.

?Worries of dilution are pushing shares down today,? said Katsuhide Takahashi, a credit sector specialist at Citigroup in Tokyo.

If all the convertible bonds were exchanged for Sony shares, it would lead to a dilution of existing share holdings by as much as 15.6%.

?In a way, the fact that Sony can issue corporate bonds and access the market is positive, in comparison to its peers that can't even do that like Sharp. From an equity perspective, there are worries of dilution but on a credit front this is positive,? Takahashi said.

Rival Sharp Corp, has effectively been shunned by the debt capital markets because of its massive losses and falling market share, forcing it to turn to its banks for a bailout in September and consider capital tieups.

A Hong Kong-based credit analyst said some investors were likely selling Sony shares in favour of the convertible bonds, which protect their investment if the share prices fell but still offered upside in the event a rally.

Despite a zero coupon, which reflects Japan's near-zero rate environment, the bonds would be attractive given a low conversion premium, set at 10% above Wednesday's close at 870 yen.

?It would be a safer bet for stockholders to buy the convertible bond as its downside is better protected relative to the equity,? he said.

Convertible bond arbitrage traders and hedge funds could also use the bonds to hedge short selling Sony shares.

?The cost of shorting Sony stock would be low and it will be easy to short, so this trade will be attractive,? he said. - Reuters

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Florida panel wants different tuition for different degrees

TALLAHASSEE, Fla. ?

Gov. Rick Scott's higher education task force tentatively agreed on recommendations that include basing tuition on the type of degree a student is seeking and letting "preeminent universities" set higher rates.

Charging different tuition rates for various degree programs could be used to encourage students to enter those fields deemed to be of strategic importance to the state's needs and economy by offering lower rates.

The Sun Sentinel reports that as part of that plan, students majoring in fields such as psychology, political science, anthropology and performing arts could pay more because they have fewer job prospects in the state. Meanwhile, students who major in fields like science, technology, engineering and math would pay less because those degrees are most needed in the state's economy.

Then panel also tentatively agreed to recommend that tuition not be increased for the next three years, or until the state's unemployment rate drops below 7 percent, for degrees in high-skill, high-demand or high-wage areas. The state's unemployment rate was 8.7 percent in September.

Source: http://www.wmtw.com/news/maine/education/Florida-panel-wants-different-tuition-for-different-degrees/-/8791950/17437584/-/12g39pez/-/index.html?absolute=true

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Google vs Doogle: School dropout faces legal battle with Internet's Goliath

JOHANNESBURG - One is among the world's most powerful corporations, a behemoth with a market capitalisation of S$250 billion (S$306 billion). The other is a loss-making website owned by a school dropout on a computer bought from a pawn shop for 600 rand (S$82).

It is Google v Doogle.

The unlikely duel has come about after a young South African entrepreneur received a letter threatening legal action because his site's name and logo are too similar to Google's.

Mr Andries Maree Van Der Merwe, who turns 23 this week, vowed to fight all the way in what his lawyer describes as a "David and Goliath" contest.

Mr Van Der Merwe, from Middelburg in Mpumalanga province, set up Doogle after dropping out of school at 16 to look for a job. It was while working as a newspaper vendor that he hit upon the idea of a site to help the unemployed.

"I sold newspapers on street corners and people told me what was wrong," he recalled. "They wanted a place where they go to find a job."

Mr Van Der Merwe found an investor and, in January last year, registered doogle.co.za, a site that allows jobseekers to upload their details for free and search online directories. "The name just popped into my head. I said, 'That's the name I'm going for - people will remember it.' I searched domain names and it was available."

Unlike Google's sprawling campus in California's Silicon Valley, Doogle is run on a shoestring. Mr Van Der Merwe said: "For a year or so I suffered. I had nothing. I'm still using a computer I bought at a pawn shop for 600 rand and it's very slow.

"I haven't made any money from the site. Sometimes I have to catch fish from the river to eat. But I think God is with me," he said.

Doogle received a million hits in its first year, Mr Van Der Merwe added, and about 10,000 yesterday alone. "Eventually I want to have a successful company and help people. I know a guy who got a job through Doogle and he's now a manager."

But the shadow of Google looms large. Mr Van Der Merwe said it had complained that his logo and search engine infringe its copyright and there is a danger that users will assume Doogle is associated with Google. He rejects the claims and has offered to place a notice on his site distancing it from Google.

"When I got a letter from Google's lawyers all I could do was smile," he continued. "I didn't expect it but I'm not going to get negative. I'm feeling good because I know the law is with me. If they want to take me to court, I will go all the way."

Mr Van Der Merwe, who earns some income as a software developer, added: "I'm not angry at Google; I'm still using their web search now. They can take me to court and we can settle this like businessmen. I will just go on. I'm still young. I have nothing to lose. I'm starting to be successful."

His lawyer, Ms Emmie de Kock, said her firm had been instructed to represent Doogle "in a possible David-Goliath battle against giant search engine Google".

She added: "The services provided by Doogle-it are distinguishable from the services of Google in the sense that Doogle-it provides online search facilities on its website for specific directories relating to businesses, job seekers, property listings and motor trading, for entries registered on its local databases."

Google declined to answer questions about Doogle directly. Ms Julie Taylor, a spokeswoman for the company in South Africa, said: "We can't comment on individual cases, but we are passionate about protecting the reputation of our brand as an objective and fair provider of search results. We simply ask our users not to shorten, abbreviate or create acronyms out of Google trademarks.

"We have to turn down many requests for use of Google brand features because sites imply that Google is endorsing them or is otherwise affiliated with them." THE GUARDIAN

Source: http://www.todayonline.com/World/EDC121115-0000118/Google-vs-Doogle--School-dropout-faces-legal-battle-with-Internets-Goliath

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Germany expanding compensation for Nazi victims

BERLIN (AP) ? Sixty years after a landmark accord started German government compensation for victims of Nazi crimes, fund administrators and German officials say payments to Holocaust survivors are needed more than ever as they enter their final years.

Most Holocaust survivors experienced extreme trauma as children, suffered serious malnutrition, and lost almost all of their relatives ? leaving them today with severe psychological and medical problems, and little or no family support network to help them cope.

In acknowledgement of that, German Finance Minister Wolfgang Schaeuble signed off officially Thursday on revisions to the original 1952 compensation treaty, increasing pensions for those living in eastern Europe and broadening who is eligible for payments. Contributions to home care for survivors already have been increased.

"Survivors are passing away on a daily basis but the other side is that individual survivors are needing more help than ever," the Chairman of the Conference on Jewish Material Claims Against Germany, Julius Berman, told The Associated Press ahead of the ceremony.

"While a person came out of the camps very young and eventually developed a life of their own over the years, the impact of what happened at the beginning is now coming to the fore. Whether it's mentally or physically, they're sicker than their peers of the same age."

Holocaust survivor Roman Kent said his experience is something that he will never be able to forget.

"Just witnessing the atrocities committed at the gate entering Auschwitz-Birkenau is more than enough to keep me awake at night until the end of time," he said.

But he stressed that he does not hold current generations of Germans responsible for the past, saying they are actually today united in purpose with Holocaust survivors.

"Both of us do not want our past to be our children's future," he said.

Germany has paid ? primarily to Jewish survivors ? some ?70 billion ($89 billion) in compensation overall for Nazi crimes since the agreement was signed in 1952.

In one change to the treaty that Germany agreed to earlier this year, the country will provide compensation payments to a new category of Nazi victims ? some 80,000 Jews who fled ahead of the advancing German army and mobile killing squads and eventually resettled in the former Soviet Union.

They became eligible Nov. 1 for one-time payments of ?2,556 ($3,253). The amendment also formalizes an increase in pensions for Holocaust survivors living in formerly communist eastern Europe to the same as those living elsewhere ? ?300 ($382) per month ? from the ?200 to ?260 ($255 to $331) they had been receiving.

Schaeuble said on Inforadio before the signing ceremony at Berlin's Jewish Museum that once Germany and the Claims Conference had identified the additional victims living in the east, it was only natural to include them in the compensation agreement.

"We still do not know the names of all of the victims," Schaeuble said. "The crimes of the Holocaust were so inconceivably enormous that you can't know all of the victims or those with claims, so you have to adjust it again and again."

Germany already increased payments this year for home care for Holocaust survivors by 15 percent over 2011, and has pledged to raise that further in 2013 and 2014.

Compensation has been ever evolving since the 1952 agreement, with annual negotiations between the Claims Conference and the German government on who should receive funds and how much will be paid.

Still, even 67 years after the end of World War II, there is much to set right, said Stuart Eizenstat, the former U.S. ambassador to the European Union who serves as the Claims Conference's special negotiator.

"One of the things that drives me is that with all of that, the best surveys out there are there are probably 500,000 survivors alive today worldwide and half of them are in poverty or very close to the poverty line," he told the AP. "This is an ongoing responsibility ? this is not the end of the road."

Eizenstat said it is a tribute to Germany and officials there that the country continues to acknowledge responsibility for Nazi-era crimes ? both with the compensation payments and also in its actions.

"I was very much taken by the degree to which they had come to terms with World War II and were dealing with its consequences, through mandatory Holocaust education; through seemingly small, but important, things like putting plaques in front of homes of Jews who had been expelled; by building a monumental above-ground Holocaust memorial right in the center of reunified Berlin," he said.

"It's a very sharp contrast to what Japan has done in recognizing their responsibilities... it's quite striking."

Conference chairman Berman said the fact that the German government decided to host an event to announce the latest results of negotiations with the Claims Conference at a Berlin event shows it remains committed.

"To me the most significant part of this event ... is that the German government wanted it ... telling again not only the whole world but more importantly telling the German people that it's not over," he said.

Source: http://news.yahoo.com/germany-expanding-compensation-nazi-victims-100038111.html

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Early Galaxy S3 Android 4.1.2 firmware leaks, multi-view feature in tow

It's been rumored previously, and now there's more evidence to suggest that the Samsung Galaxy S3 will be getting the "multi-view" feature from the Note 2 in its upcoming Android 4.1.2 update. An early, leaked version of the ROM obtained by SamMobile also adds many other Note 2 features, including smart rotation, Paper Artist, a new gallery app and the Note 2's SwiftKey-powered keyboard.

For the uninitiated, multi-window allows you to split the screen between two full-fledged Android apps by long-pressing the back key. It wasn't quite ready for the Galaxy Note 2's launch, but was added in an over-the-air update few days later.

Today's leaked firmware is a pre-rooted testing build that's been cobbled together based on a system dump, so all the usual warnings apply. As it's not officially signed by Samsung, flashing the firmware will increase your custom binary counter, too.

The Galaxy S3 isn't the only device rumored to be getting multi-view. There've been whispers in the past few weeks suggesting that the original Galaxy Note (international version, GT-N7000) could end up with some of its big brother's showcase features, in addition to the new TouchWiz Nature UX -- as part of its Android 4.1.2 update.

There's no official timeframe for the Galaxy S3 to receive Android 4.1.2, but SamMobile seems to think the company's aiming for a December release on international models.

Source: SamMobile

Source: http://feedproxy.google.com/~r/androidcentral/~3/XQwvi56VT8o/story01.htm

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