Sorry, Readability was unable to parse this page for content.
Source: http://video.msnbc.msn.com/nightly-news/49631804/
cleveland browns minnesota twins bobby abreu 2012 draft colt mccoy arbor day mike adams
বুধবার, ৩১ অক্টোবর, ২০১২
Cyclone/Hurricane Sandy: October 31, 2012 Gartner Blog Post ...
Roberta J. Witty
Research VP
11 years at Gartner
33 years IT industry
Coverage Areas:
by Roberta J. Witty ?|? October 31, 2012 ?|? Submit a Comment
One of the things I take seriously as a part of my job is making it easy for Gartner clients to get access to our research in a timely manner. So here is the list of Gartner BCM Blog posts related to Cyclone/Hurricane Sandy. I?ll compile a list every day so that you can easily find everything you need.
You might also find our?Research Roundup for BCM and IT-DRM?useful to find our published research on all topics related to business continuity management and disaster recovery.
A Post from My Colleague Allen Weiner: Lack of Social Media May Foil Free Taco Marketing Plan (this is about Hurricane Sandy) #Sandy
A Post from My Colleague Andrea DiMaio: Hurricane Sandy Confirms the Tactical Nature of Social Media #Sandy
A Post from My Colleague Bill Gassman: Three Marketing Lessons from Hurricane Sandy #HurricaneSandy #Sandy
A Post from My Colleague Craig Roth: The Impact of Hurricane Sandy #HurricaneSandy #Sandy
A Post from My Colleague Donna Scott: Is Power Recovery your Weakest Link? #Sandy #HurricaneSandy
A Post from My Colleague French Caldwell: Expect to Hear About How Social Tech Enabled Self Relief in Sandy #HurricaneSandy #Sandy
A Post from My Colleague Jay Heiser: Electrical Fragility #Sandy #HurricaneSandy
A Post from My Colleague Jim Duggan: Recurring Lessons Learned from Major Disasters #HurricaneSandy #Sandy
A Post from My Colleague John Morency: What Can be Learned about Cloud?based Recovery in the Aftermath of Hurricane Sandy #Sandy
A Post from My Soon-to-Be Gartner Consultant Colleague Belinda Wilson: Thoughts On Crisis Declaration and Interdependencies #Sandy
Good Advice from Ready Campaign ? U.S. Department of Homeland Security ? Washington, DC 20528 ? 202-282-8000 #HurricaneSandy
Post-Sandy Advisory No.1 #Sandy
Sign Up For Your Area?s Emergency Alert Messages
Some Unique Pointers from Two Webinars I Attended ? October 29, 2012 ? #HurricaneSandy
VERY Practical Hurricane Sandy Advice from Arnold Chase on the Colin McEnroe Radio Show ? #HurricaneSandy
Hurricane Sandy: How Many Emergency Alerts Did You Get, From Whom and How Effective Were They? ? #HurricaneSandy
?
Category: Advisory BCM Process Event Technology ? ? Tags: Allen Weiner, Andrea Dimaio, Application Development, Belinda Wilson, Bill Gassman, Business Continuity Management, Business Continuity Planning, COOP, Craig Roth, crisis communications, Crisis Management, Disaster Recovery, Donna Scott, Emergency Management, Emergency Notification, Emergency Preparedness, EMNS, ENS, FEMA, French Caldwell, Governor Christie, Hurricane Sandy, IT Disaster Recovery, Jay Heiser, Jim Duggan, John Morency, marketing, Mass Notification, Roberta Witty, Sandy, social media, supply, Telework, Third Party Risk, virtual, virtual machines
st bonaventure ncaa tournament 2012 peyton manning 49ers andy pettitte tyler clementi kevin kolb sarah shahi
Poikos Takes The Prize At The Pioneers Festival In Vienna ...
The Pioneers Festival kicked off in Vienna this week and by the looks of the 2,300 attendees at the amazing Hofburg Imperial palace, the conference is shaping up to be a stand-out event in Europe, not least because it is enormously upbeat and positive. Something we need more of in Europe. With a palace as a setting, art installations and a Croatian-born electric super car in the foyer (the Rimac), this is quite a ?European? event. The location of Vienna also means it?s attracting a lot of German, Austrian, Central, Eastern and Southern European startups. Hell, they can drive or get a train here from just about anywhere in Europe. Poikos a startup with a technology for imaging and measuring the body in 3D, was the overall winner in the startup competition, winning ?25,000 prize money. Klash won the audience choice. Helioz won second place and BeamApp won third place. So here?s a fast run-down of the startups appearing, you can grab links to them from this page.
Poikos
Their pitch: ?Poikos is a computer vision systems house which has developed a revolutionary patent-?pending technology for imaging and measuring the body in 3D, using consumer grade hardware such as smartphones, tablets and PCs. ?We are developing a platform for the delivery of our technology to partners within the fitness, entertainment, health and e-?commerce sectors, for a range of amazing new capabilities across all industries. The processing is cloud-?based, and we have worked with 9apps.net to ensure the scalability of our infrastructure. In terms of revenue, we charge app developers service and support charges on-?going, commensurate with use. For corporate clients, we have an expected revenue-?based licensing fee structure. We already have some of the largest e-?commerce companies in Europe and beyond signed up to license our technology. We have massive interest from the bespoke apparel, and health & lifestyle sectors also.
Gabi
Their pitch: ?Gabi is the first social network assistant that tells you all the gossip happens in Facebook. A B2C personal analytics tool that will allow you to discover hidden content. With Gabi users have the control about what they want to see. Gabi learns, and tells users social suggestions about the most relevant content, such as which of my friends are the single girl most liked. Or: ??Dude! Alex Moore has a lot of friends in common with you. Is that true in real life too or are all these people just acquaintances? Gabi keeps you updated about the coolest things happens in Facebook. Your daily Facebook gossip.
Babelverse
Their pitch: ?Babelverse is the universal translator of the spoken word, a platform for real-?time
?interpretation powered by people, in any language. After disrupting the conferences
?industry (and making live video available in multiple languages, for people who
?would be unable to attend, let alone understand), Babelverse will soon allow
?anybody to benefit from on-?the-?spot interpretation, over the phone or via the
?internet, during their everyday conversations, when doing traveling, for business, or
?any situation where they find themselves needing to communicate in a different
?language, for around the cost of a taking a taxi. It also provides a new source of
?income for skilled multilinguals and professional interpreters alike.
Showroom
Their pitch: ?SHOWROOM is a complete e-?commerce solution for independent fashion designers.
?It allows them to sell and promote their products in three on-?line channels: their
?Facebook fanpage, own website, and multibrand shwrm.com. SHOWROOM is fitted
?with useful tools for managing stock, invoicing, shipping (integration with the UPS
?logistic system) and promotion in social media. We launched in January 2012 and
?already are the biggest marketplace with independent fashion in Poland, with more
?than 400 designers and brands using our platform on a daily basis. In March 2012
?we?ve received a seed financing from a Polish VC HardGamma Ventures, and right
?now we are closing down the Series A round that will let us expand internationally.
Flat-?Club
Their pitch: ?Flat-?Club is LinkedIn for Short-?Term-?Renting. Helping alumni & students of top
?universities find short term accommodation by leveraging existing social networks to
?create trust. With this pitch (&the idea behind it) we won the TechCrunch 2012 One
?Sentence Pitching Challenge ? ranked first out of 650 startups globally.
?We launched in London with 5 flats 18 months ago and grown to over 2,000 flats &
?rooms in 20 cities within a year. By focusing on a niche market, we developed a
?tailored solution which is already being promoted by 30 top universities including :
?Columbia Business School, INSEAD, King?s College, LSE, IESE, and others. Flat-?Club is a member of London Business School Incubator and Google Campus and is based in
?London.
Bevelity Design
Their pitch: ?Bevelity offers a professional subscription-?based software platform that lets our users Create, Publish and Share interactive 3D on the web.
2011 saw how $14 Billion were invested by 26 million by creative 3D professionals to:
?? Develop awesome 3D apps, games for mobile devices, digital signage, smart TV and the internet
?? Create engaging adds and multimedia content
?? Create CAD designs, for architecture, industrial design and product configurations
Putting this on the web is a challenge.
Eisenhower
Their pitch: ?EISENHOWER is a bootstrapped task management solution based on the proven
?Eisenhower matrix time management principle.
?Built with simplicity in mind, we provide you with a suite of software applications
?and tools to focus and work on the most important tasks, including a free web app, a
?paid iPhone app and and the Eisenhower matrix printed on paper notepads for
?people who prefer to keep track of their work offline.
?While helping you to prioritize and plan easily, EISENHOWER minimizes stress on the
?one hand and increases productivity on the other by focussing on supporting you to
?actually complete tasks, not only compile never-?ending lists.
?We are also offering B2B services like time management trainings and high-?volume
?notepad orders.
10Stamps
Their pitch: ?Digital has been an essential part of how we build our brand and connect with our
?customers [...]? Adam Brotman, CDO, Starbucks. This quote highlights the ever-?
?growing importance of Internet also for personal service businesses like a coffee
?shop. The increasing distribution of smartphones enables local businesses to use
?marketing tools that have so far only been available to the online world. This leads to
?a huge shift of marketing spending away from classic marketing towards individual
?communication with customers through their smartphones. 10stamps offers simple
?but powerful mobile customer loyalty solutions for local merchants ranging from
?international franchise enterprises to mom-?and-?pop-?stores. Restaurants, leisure,
?wellness, and personal service providers use 10stamps to start, understand, and
?develop the relationship with their customers.
Augment
Their pitch: ?Augment is a mobile app that lets you visualize the 3D model of any product in your
?real environment, in Augmented Reality, through your tablet or smartphone camera.
?Augment provides the ?Try at home? button to e-?commerce sites, so their audience
?can try furniture, artworks or tech products at home before purchase.
?Augment is also a sales tool for salespeople in various industries, including
?merchandising, swimming pools, real estate and interior design.
?The market for music licensing is currently valued at $2.5 Billion. However, gaining
?access to this market is largely restricted to established companies. By providing the
?technological infrastructure between musicians and content users, rightclearing
?democratizes the market for music licensing. Independent artists and labels can now
?earn money with the usage rights to their music, even without profound legal
?knowledge. Advertisers, filmmakers and others can license songs with only a few
?clicks. rightclearing uses cutting-?edge technology to digitalize and automate the
?process of music licensing. Within minutes a licensee can find the right song, close a
?legal contract with the rights holder and download the song file in the desired
?quality ? all without lawyers and long-?winded negotiations.
MercuryPuzzle
Their pitch:
-? The problem: Business networks have introduced online recruitment a while ago, but cannot deliver the data companies need to decide who is the right person for a job.
-? The solution: MercuryPuzzle identifies talents and matches them with satisfying jobs.
-? Our secret sauce: We provide scientific assessments and a variety of cognitive tests. As a new approach to 360? feedback we introduced ?TalentMash?, letting users evaluate each other?s talents. Additionally, we offer a traditional CV interface. The in-?depth candidate reports generated by these tools can be filtered and searched by recruiters.
-? The outcome: Recruiters find great talents online. These talents get offered positions where they can do what they love and what they are best at.
Klash
Their pitch: ?Have you ever challenged someone to stop smoking, drink more beers, run a marathon, walk around in a mankini or dared someone to pick up more girls or guys on a bar night out?
The iPhone app makes it really easy to ?klash? your friends. Simply pick a facebook-? friend, define your Klash, and set a fun reward. Get your friend ?s support, post comments, add proofs and share the fun in your community. It is up to you if you want to challenge a friend or even the whole world.
Sketchfab
Their pitch: ?Sketchfab is a web service to publish interactive 3D content online in real-?time
?without plugin. The world we live in is in 3D, but the web is still in 2D, and we want
?to change that. We think 3D models deserve something better than screenshots or
??showreel? videos. Our product is a universal 3D viewer you can embed on any
?webpage. It?s a bit like youtube, but for 3D files.
Helioz
Their pitch: ?Helioz R&D is a social entreprise engaged in the development, research and sale of
?affordable and efficient tools for low-?income households, humanitarian
?organizations, emergency aid organizations and companies around the globe. Helioz
?R&D is focusing to find innovative solutions to society?s most pressing social
?problems. To tackle the world water crisis, Helioz has developed an inexpensive and
?easy-?to-?use device, especially adapted for the Base of the Pyramid (BoP). The use of
?WADI (Water Disinfection) is simple and does no need any further training: It is out
?on a water-?filled PET bottle like a screw cap and indicates the microbial reduction in
?water through solar disinfection illustrated by a smiley face. The patented device
?WADI is made of recyclable plastic, works energy self-?sufficient with its built-?in solar
?panel, and is maintenance-?free for at least five years (guaranteed!) ? At the
?estimated costs of around 10 dollars per piece.
RiseArt
Their pitch: ?Rise Art is the easy way to discover great art you love from top artists, galleries and
?museums worldwide. ?Take our free art style quiz and get expert art picks from our curators based on your
?unique taste. When you find something you love, you can buy it, or Rent it, and
?enjoy the artwork in your home before deciding to purchase. Love your art? Rent it
?for as long as you like or buy it using credits from your rental. Otherwise, just return
?the artwork free of charge at any time. Rise Art launched our art rentals in 2012 and
?are now working with global brands including the TATE, and Serpentine Gallery.
?Get Started and discover your art style by visiting.
Beamapp
Their pitch: ?BeamApp connects your various devices so you can instantly transport your ongoing
?activity from one device to another. Whenever you encounter a situation on the
?desktop that makes more sense on your phone just ?beam? it across and continue
?on the go. You finally found the phone number in an email? Just ?beam? it to
?instantly dial it on your phone! When you arrive at home you can continue to listen
?to the music you enjoyed on the go. After planning a route on your tablet you can
??beam? it to your mobile and immediately start the turn-?by-?turn routing.
DotProduct
Their pitch: ?DotProduct has developed technology that enables easy and robust capture of 3d
?models from real-?world objects in seconds. Our product is portable, self-?contained,
?operates in real-?time and generates ready-?to-?use results instantly. It is a tool
?targeted towards professional users from the AEC, oil & gas, aerospace/defense and
?forensics industries with possible future applications as a consumer technology. It is
?built from solid off-?the-?shelf hardware, enabling a price point that is 1-?2 orders
?of magnitude cheaper than existing solutions.
?We bridge the gap between virtual 3d/CAD models and real-?world existing
?conditions, solving the workflow and accessibility problems that come with existing
?3d solutions. Our vision is to bring smart 3d-?aware tools out of their niche and make
?them accessible and affordable for everyone.
THE REST
Omyconf:
Their pitch: ?Omyconf! connects professionals to global business events and top contacts, immersing them into interaction before, during, after events.
On the annual global market of 1M conferences professionals still don?t have any single resource to access event content and network; organizers lack proper solution to cover multiple layers of interactivity.
With our open Event Interactive Platform organizers:
-? crack the problem of messy conference networking even on hybrid events with smart location-?based networking and planning tools -? sell tickets to access event content even after the event -? manage full-?life event cycle
We?ve successfully connected over 30K professionals on 40 events in Russia (incl TechCrunch Moscow) and Ukraine.
Omyconf! is THE future standard in the mass event industry like Foursquare for local businesses and LinkedIn for professional communication.
Nexi:
Their pitch: ?Nexi is changing the way businesses hire their most talented people. Every CEO and HR Specialist knows that job boards are useless and that agencies are extremely expensive.
Nexi provides a brilliant new way of recruiting, through referrals from the employees. We built a social referral platform, where employees can easily refer their friends from LinkedIn, Facebook and Twitter. They win cool rewards and even cash prizes if their friends are hired.
We graduated from Rockstart Accelerator and now we?re working with 15 european companies to improve the product. We?re happy to be part of Pioneers Festival
Instabridge:
Their pitch: ?By utilizing the social graph (Facebook, LinkedIn & Twitter) Instabridge allows users
?to share Wi-?Fi with friends, family and colleagues in a secure and hassle-?free
?manner. This unlocks Wi-?Fi in offices and homes and makes it easily accessible to
?consumers, reducing mobile data usage by 10%-?20%. As mobile data usage is
?exploding Instabridge can save carriers billions of dollars. Be sure to check out our
?first blog post http://blog.instabridge.com/post/27904447274/unlocking-?the-?worlds-?
?wi-?fi for some additional backdrop and sign up at http://www.instabridge.com to get ?early access to our app.
Mirror Bird:
Their pitch: ?The new, breakthrough way of advertising. Mirror Bird device looks like usual mirror ?from the first glance. The system recognizes the gender of approaching person; the ?mirror turns into the screen and shows the commercial oriented to appropriate ?gender. The advertisers will be pleasantly surprised! The efficiency of ads showing ?increases in 5 times! Mirror Bird allures people and attracts them into your place! ?MirrorBird changes our view on the media devices. Three major features break the
?stone of advertising blindness. It?s attractive, convenient and efficient
?simultaneously. Mirror screen, Gender targeting, MirrorBird Administration panel ?
?these are 3 major breakthroughs that in conjunction make MirrorBird one of the
?best solution for commercial showing.
Tedcas:
Their pitch: ?In nowadays Operation rooms and Radiology rooms there are a lot of displays with
?digitial information that has to be access by Medical Doctors in real time, while
?keeping the Room sterile. What Doctors do now is either going out of the Room,
?consulting the information, memorize it, getting sterile and go inside the room again,
?which takes for about 20 minutes or, alternatively, put some computers or
?touchscreens inside the Room which puts into risk the sterilization.
?In TedCas we solve that by using our Natural User Interfaces which through the use
?of an optoelectronic device (for example the Kinect camera) allow the Medical
?Doctors to control any kind of medical software through voice and gestures, without
?any contact and therefore avoiding bacterial infections of this kind
Qunb:
Their pitch: ?Need market volume and competition figures for your business plan? Need facts to raise public awareness about climate change? Need to put your corporate sales into perspective with weather or traffic?
qunb is a ?one-?stop shop for numbers?, a quantitative data aggregation platform. Trillions of data points, sourced from thousands of top data providers, seamlessly chartable and cross-?comparable.
qunb lets any user find any data about any matter whatsoever, and lets you seamlessly create a consistent chart, either to use online (embed in your blog) or offline (in your powerpoint presentation).
Or say it that way: qunb is the result of a night of love between BigData and Business Intelligence?
Uniplaces:
Their pitch: ?UniPlaces brings together students and property managers on our simple and user-?
?friendly platform, making it a breeze for millions of students around the world to
?find a new home.
?The number of students is expected to double within the next 10 years to over 260m
?worldwide. This creates an urgent need for one trusted platform to help them find a
?place to stay where ever they choose to study.
?Universities cannot serve this need alone and with 25 university partners, over
?17,000 listings and tens of thousands of students visiting us each month, we are
?already tackling this growing, global need.
Xcessity:
Their pitch: ?On a daily bases we share our ideas, thoughts and feelings with the people around
?us. Besides verbal communication we use many other means to transport
?information effectively. We express ourselves using body posture, gestures, facial
?expressions and eye gaze. This nonverbal communication is very essential in social
?interactions, yet when it comes to human-?computer interaction we are limited to
?use our hands only. New sensor technologies make these powerful sources of input
?available and still we rely on our fingertips to control computers, phones and tablets.
?Now is the time to tap these sources and finally give them the same value as in face-?
?to-?face communication ? Xcessity software solutions, providing unlimited
?accessibility for everyone.
Hoa?s Tool Shop:
Their pitch: ?Hoa?s Tool Shop creates digital tools for personal development through behavior change. Our mission is to help people actively work with their psychological well being.
Viary, our first product, is used by therapists and coaches to create a digital layer on top of an often very analog field. Data gathered through our mobile app allows the professional to measure progress, provide better feedback, and increase precision in their efforts.
Our next step is a product where the professional is replaced by an artificial intelligence. By using user data to automate and personalize the process we can create an even more efficient solution. The supply and demand of mental healthcare is unevenly distributed. We want to change this
A*Space:
Their pitch: ?Millions of patients with urinary tract infection suffer through doctor visits, clinical laboratory visits, and finally have to wait 24 to 72 hours for results, often receiving unnecessary antibiotics. Elderly, pregnant and children could benefit from rapid, reliable urinary tract infection diagnosis through smartphone devices.
Our product, complementing smartphones, enables point-?of-?care centers screening patients in minutes instead of cumbersome clinical testing in days. We envision hassle-?free urinary infection diagnostics in the comfort of your home, displaying results on your smartphone, contacting your family physician per SMS or Email with results.
Benefits for patients: immediate feedback and relief. Benefits for physicians: precise and rapid diagnostics before entering ambulance.
?Benefits for Points-?of-?Care: no need sending samples to a centralized lab, saving workforce.
Honestly:
Their pitch: ?Honestly develops a Software-?as-?a-?Service plattform which enables serviceoriented
?companies to collect, analyse and manage customerfeedback. Endcustomers send
?their feedback via Honestly?s mobile applications / mobile website, which
?guarantees the easiest feedbackprocess possible and an innovative aftersales
?contact.
?Compared to traditional technologies, customerfeedback via Honestly is instant,
?localized, non-?public and digital. Honestly guarantees companies a greater rate of
?return, it is easy to integrate into existing IT-?platforms and because of the SaaS-?
?model has no initial costs.
?The technical founderteam has bootstrapped the platform for a year and raised
?money from business angel Klaas Kersting and per crowdfunding. Paying customers
?exist in sectors like education, hospitality, retail and event, with the current focus on
?major enterprises in healthcare, gastronomy and exhibition.
Diabeto:
?Diabeto is a non-intrusive bluetooth powered hardware device, which enables the
?transfer of glucose readings from your Glucometer to any diabetes mobile application
?for easy tracking and manageability.
Richseam:
Their pitch: ?When it comes to discovering new music, there?s nothing quite like a personal recommendation. And what better if it?s from the musicians themselves? Their collaborations and connections speak louder than words: artists work with those who inspire them; bands swap and share members with similar groups; musicians tour with complimentary acts.
We?ve collected & curated all of this information to provide a unique music discovery service. We base our recommendations on real-?life relationships, not other peoples? listening habits. And you can immediately see how and why artists are connected, helping you find out more about the music you love
Sunstance:
Their pitch: ?Everyday we are surrounded by digital technology like computers and mobile devices. But even in 2012, hand sketching and drawing is the easiest and the fastest way to iterate over concepts. We use paper to share, work and collaborate. In effect, in the world where most of our work happens online, the results of the design phase are left in the analog world, disconnected, not shareable, and easily forgotten.
With Substance, you can finally, using your smartphone, transfer your hand drawn sketches into editable interactive models. Transform your business model flowcharts and schemes from analog flipchart into digital form. Using Substance, website developers and UX designers will be able to get feedback from their clients on-?the-? fly.
Panamnav:
Their pitch: ?BEWISE by PanamNav is the definitive solution to authenticate space/time anywhere in the world.
This world is becoming digital and mobile, we are all dynamic avatars in the cloud. And then you need to show that you are here and now.
When you need trusted position in social networks or go shopping with your mobile wallet, when you travel on a road without barriers or want to have fair insurance, when you need safe banking or data exchange, when you need reliable telecom service and power grids? Whenever you need to authenticate your virtual profile, BEWISE will be by your side, to provide trust and reliability in human relationships. The key to foster economy in the XXIst century.
Tanaza:
Their pitch: ?Tanaza provides a centralized cloud-?based solution (SaaS) to manage Wi-?Fi Access Points. Tanaza approach eliminates the need for an expensive, dedicated hardware controller and is compatible with consumer and SOHO level Wi-?Fi Access Points of 3rd party vendors, such as Netgear, TP-?Link, D-?Link and Ubiquiti.
The company aims to enable operational efficiency to Systems Integrators and Managed Solutions Providers that work in the SMB space (Small Offices, Hotels, Hospitals, Schools, Colleges). No more one-?by-?one manual configurations, even on autonomous devices, less time for daily maintenance tasks, remote management and monitoring through Tanaza web interface.
Tanaza leverages compatibility with 3rd party devices as well as a social approach to customers to create a vendor-?agnostic community that can lower the acquisition-?cost of SMB customers to a sustainable and scalable point.
Fixational:
Their pitch: ?Fixational delivers eye-?movement gesture control for mobile devices. The software engine sits in the background of any app, observing and analysing user?s eye movements through the forward facing camera. Developers can hook into recognised gestures, such as winks, enabling a whole new way of controlling devices.
?The goal is to license this technology to OEMs. This will be achieved by building a user base through the App Store and releasing an SDK for developers.
Fixational was founded by Ronan O?Malley and Diarmaid ? Cualain, experts in developing complex computer vision software systems, having completed PhDs in self-?driving vehicle technology. They are graduates of Ireland?s top startup accelerator: Launchpad.
Their first app ?Wink Camera? was recently featured by The Next Web.
Concept Inbox:
Their pitch: ?Concept Inbox is a tool for designers to request feedback from clients and get designs approved quickly.
It?s made by designers for designers, we know that this work has a very tough side to it? the questions, last minute changes, endless calls?
With Concept inbox, all the designer has to do is send their designs to an email address that we provide, specifying the project name in the title.
Automatically, this will generate a common workspace where designer and client will be able to share opinions easily.
With Concept Inbox, designers can manage their projects with a single tool, avoiding distractions and focusing on what really matters: getting faster approval, saving time and money.
Concept Inbox, Get designs approved faster.
Kippt:
Their pitch: ?Kippt (YC S12) is a social knowledge management platform. Individuals and companies can collect and share the knowledge they research, and discover new valuable information from the community.
The platform is already helping and saving time wide-?range of professionals like designers, developers, market researches, journalists and companies as well as research organizations every day.
Xeer:
Their pitch: ?Xeer is the smart way to manage your business: Collect receipts, send invoices,
?manage your team, projects and make your business rock ?n? Roll! Xeer is super easy
?to use: You can scan receipts with your smartphone, Xeer will analyze the receipts
?and fill out information like date and amount. This way, everything is in perfect
?order. Always! And at the end of the month, you can send your receipts digitally to
?your accountant or tax consultant, or you can let Xeer do the bookkeeping for you!
?So everything is done, with just one click.
Tjobs:
Their pitch: ?TjobsRecruit is a hybrid online/bricks-?and-?mortar business that for the first time
?combines the efficiency of an online recruitment portal with a fast growing
?proprietary network of over 500 recruitment agencies. We make use of the full
?breadth and depth of internet technologies and network effects to enable enterprise
?clients to tap into our recruitment capacity of well over two million qualified
?temporary or permanent candidates, and experience world-?class post-?recruitment
?support. Our online portal also provides partner agencies with useful workflow tools
?and marketplace functionalities, while candidates find a constant stream of up-?to-?
?date high quality job offerings. TjobsRecruit works on innovating the global HR
?Services sector by improving the efficiency of the recruiting process for all
?stakeholders: employers, candidates and agents.
Toytemic:
Their pitch: ?Toytemic (founded in 2011) is aiming primarily toy robotics. In near future the
?technology extensions will apply as well to service robotics, presentational
?equipment and mission critical systems.
?The technology supports coordinated maneuvers of self-?propelled devices. The
?devices, each containing an inexpensive built-?in RF IC module, detect mutual
?position accurate within 2cm. No external tags, beacons or cameras are required.
?First invention patent granted. Three PCT applications pending. Next five in
?development.
?Prior to releasing its break-?through positioning system Toytemic plans to occupy a
?place d?armes on target market segments with a series of niche products. For
?instance, a universal remote controller looking like a conventional pointer will be
?used for controlling an arbitrary number of units (tens and more).
Liquidweb:
Their pitch: ?BrainControl is a breakthrough technology that will give disabled people the power
?to control objects with their minds, allowing them to control a communicator,
?domotic devices (lights, doors, windows, alarms, temperature, bed position, etc.),
?wheelchairs, and other and other assistive technologies.
?Based on a proprietary Brain-?Computer Interfaces technology (BCI), BrainControl
?interprets the electric map that correspond to a certain brain activity, and allow
?patients to control a tablet PC through specific thoughts, overcoming physical
?disability, and improving communication and environmental control.
?Main focus is on assistive applications for people affected by degenerative
?neuromuscular disease (multiple sclerosis, amyotrophic lateral sclerosis ? ALS) and
?ischemic or traumatic injury, which each year affects more than 3 million patients.
Newsgrape:
Their pitch: ?Newsgrape analyzes nearly a quarter million articles each day from a growing
?number of sources, tailoring content to personal interests and preferred sources,
?while ranking articles according to their performance on Twitter and the activity
?inside Newsgrape. By combining social intelligence with smart filtering Newsgrape
?allows you to be egoistic on what news you get, while still giving you the most social
?reading experience out there. It is the first social news reader, that does not only
?look at your personal interests or perhaps what your friends might like, but that
?actually connects people who share similar interests and allows readers to engage in
?discussions as the news unfolds.
Tractive:
Their pitch: ?Tractive is a hardware/software solution that allows a pet owner to locate his pet at
?any time, anywhere and get notified if it leaves a user-?defined area. Tractive mobile
?applications will not only allow managing pet information and photos, but also sync
?the information across devices. Tractive apps will integrate with Facebook to allow
?users to see their friends? pets, share photos and other pet information. Leveraging
?social networks and extending them to pets will help to virally grow brand
?awareness.
?The combination of an experienced leadership team, two strong partners (runtastic,
?Krippl-?Watches) and a large untouched market make Tractive a once-?in-?a-?lifetime
?opportunity. Tractive has already secured significant seed funding and is expected to
?launch in 2013.
TaDaweb:
Their pitch: ?In one short year the TaDaweb team has managed to transform 10 years worth of
?revolutionary research into a successful company. Having made enterprise-?version
?sales pre-?incorporation, closing two rounds of finance, being selected as one of
?Benelux?s most promising startups, and now comprised team of seven day to day
?employees, plus a kick-?ass management team: TaDaweb is changing the way you
?interact with web information! TaDaweb enables you to extract the relevant web
?data you need from websites, transform it, then output it anywhere! What?s more,
?TaDaweb saves the process of how you obtained your data, enabling it?s replay
?automatically, when you want it. When others save stagnant web information,
?TaDaweb gives you customized and current information!
Tellyo:
Their pitch: ?Tellyo is about grabbing video clips from TV programs and sharing them to the
?world. We make it easy and instantaneous with just one click on a smartphone,
?tablet or web client. There is no need for special HW for recording, no need for
?scheduling the recordings and no need for video editing SW either, as Tellyo
?provides the exact moment that the viewer has just seen and liked on TV. Tellyo
?supports TV brands? efforts to reach out to new screens and to new audiences. TV
?networks benefit from viral customer acquisition.
Linemetrics:
Their pitch: ?LineMetrics is a cloud-?based production analytics service for small and mid-?sized manufacturing companies. We help our customers to identify problems in their production and show optimization potential. As a result they can make fact-?based decisions, save money, and become more competitive.
We provide our own datalogger box which makes connecting industrial machines to our service so easy, that our customers can do it on their own. We eliminate common barriers for SMEs: our rent model avoids high entry costs, simplicity replaces the need for external experts and setup time is shortened from several months to two days. If you need a catch phrase: we are Google Analytics for the manufacturing industry.
Genomics:
Their pitch: ?X&Y Genomics envisions a world where everyone has the freedom to understand,
?talk about, and share their personal genetic information.
?On the ?DNA by Me? platform, you can visually interact with your genetic
?information by discovering how your behavior influences the shape of the object and
?thus enabling you to know what you can change.
?The platform has two main components: 1) An algorithm that takes the results of a
?genetic scan and turns them into 3D-?printable shapes. 2) A web-?based 3D
?configurator that allows users to customize and personalize their physical objects.
?X&Y Genomics combines science, technology and aesthetics to create tools that
?empower people.
ZetUniverse:
Their pitch: ?Are you a PM or business analyst, owning multiple projects and tasks? Have too much of information to bet on your memory to recall it? Is it hard to recover from interruptions?
You are not alone; According to BaseX, Information Overload costs US economy ~$1T per year!.
Enter Zet Universe, beautiful infinite desktop for laptops and slates.
Organize your work information as you think about it,
Use your spatial, associative, or temporal memory to recall your past work,
Use content recommendations to get relevant bits of your past work you cannot recall at your own.
?Zet Universe helps information workers in critical roles (PMs, analysts) to process information faster and make informative decisions at their work.
http://www.facebook.com/ZetUniverse http://www.angel.co/Zet-?Universe
Xtendi:
Their pitch: ?Xtendi is developing an online studio for creating Augmented Reality experiences to design digital layers on physical objects using a simple ?drag & drop? interface.
Xtendi?s studio offers a unique proximity feature that adds a new level of exploration. Users can interact with objects in their surroundings based on their natural human behavior.
Unlike others, we believe that the potential of the technology resides in the USER, that?s why our focus is on the USER INTERACTION aspect of technology.
Just as in the real world when something interests you, you get closer to it to learn more about it, or sometimes you take a step back to see the wider context, Xtendi is mimicking this natural human behavior with technology.
EduKoala:
Their pitch: ?In EduKoala we belive that learning is a boring activity. This is why we are changing
?education into fun by creating games which engage people and help them to acquire
?knowledge. Our solution is directed to pupils who can use our platform to prepare
?for classes in entertaining way. Students are opening the app not to learn but to
?play. By the way, they are learning. Engagement increases effectiveness . Our huge
?goal is to change how next generations will educate. Our first game, MyKoala, is
?available in Google Play and helps in learning languages.
Hubbub:
Their pitch: ?Hubbub is a voice micro-?blog that extends social networking opportunities to situations when you cannot type and read: like driving, jogging or washing dishes.
?A Twitter for voice?, Hubbub allows users to record and share 30-?second voice messages, called ?bubs?, which are then combined into a smooth uninterrupted stream. The followers can then listen to the stream mixed with their favorite sounds from iTunes, Spotify, Last.fm or any other music app.
?Record your bub on the go in a few seconds ? and broadcast to thousands of followers, adding pictures, text, geo-?tags, etc. All your bubs will be automatically cross-?posted to your Twitter feed.
Hubbub makes the next step in evolution of radio by introducing to it a strong social component.
Source: http://techcrunch.com/2012/10/31/poikos-takes-the-prize-at-the-pioneers-festival-in-vienna/
2012 nfl draft grades young justice nfl draft d rose iman shumpert mayweather vs cotto shumpert
B2B Marketing Myth-busting, Redux | Biznology
Photo credit: Wikipedia
It?s always a good to examine what beliefs we are operating under?if we have?false?beliefs that are not examined, then we continue to act on them. B2B marketing is no different?what are the myths that we might believe that are possibly guiding our actions in the wrong direction? With a tip of the hat to Bob Bly, whose June article in Target Marketing magazine dispels 7 B2B marketing myths, I?d like to tackle some myth-busting of my own.?
Myth No. 1:? Lead generation is the top job of B2B marketers.? There is overwhelming evidence that B2B marketers consider lead generation their most important contribution.
So why, you may rightly wonder, am I calling this a myth?? Well, maybe it?s more of a misconception than a myth.?? But I am arguing that the true top job of B2B marketers should be customer retention, or customer penetration, which is where all the profit lies.
Of course, we need to feed the funnel, and lead generation is of course a close second priority.? But for delivering real value to shareholders, marketing should be spending considerably more effort on supporting the goal of extracting value from the customer relationship.
In B2B, this might mean strategies like:
- Identifying potential needs in current accounts through data analytics, and providing sales people with reasons to call into the account and pursue those opportunities.
- Setting up Advisory Boards by key customer segment, to gain insight into customer needs and future buying trends.
- Producing ongoing outbound marketing touches to expand the reach of the sales force in communicating value to current accounts.
My point is that retention should be viewed as a top priority, dispelling the myth that if marketers generate tons of leads,?they?ve?done their job.
Myth No. 2:? Social media is a flash in the pan.? B2B marketers are embracing social media with gusto, but many still view it as a toy, something to play around with, most likely in the corporate communications or PR departments.
Wrong.? These channels are ready for revenue generation.? I ran across a fascinating example of this at the DMA12 conference in Las Vegas last month, where Cheryl Mikovch of IBM shared the story of how the marketing team that supports inside sales has enabled reps over the past couple of years to use social media to identify opportunity and deepen their account relationships.? The result?? For one of IBM?s public cloud offerings, 15% of the closes via inside sales could be attributed to the social selling effort.? When it comes to IBM revenue levels ($107 billion, worldwide, through all channels), that?s a lot of money.
The IBM social selling journey began with a market audit that showed 37% of IBM buyers have used social media to engage with IT vendors, and that 77% of customers were very or somewhat likely to do so in the future.? So IBM understood they had to be there, with vigor.
The next step was to build a scalable, replicable social selling process, beginning with listening and engaging clients and prospects, and getting involved in the discussion?earlier than the competition.
Tactically, the process features a ?rep page,? where every inside sales rep (this means lead development teams and product specialists, as well as quota-bearing account reps) has a dedicated URL, filled with social media tools, to build his or her web presence and engage in direct communications.? The marketing department provides professionally written content, some fed automatically to the rep page, and some available for the reps to pick up according to their needs.
The marketing team also provides training to the inside sales reps, showing them how to engage effectively at groups and discussion boards, to listen and contribute, to compose tweets and create their own video messages.
Word of social selling?s success has spread among IBM reps on 170 countries, primarily through rep word of mouth. Helping drive 15% of public cloud inside sales, this thing is no myth.
Myth No. 3: Old media are dead.? Au contraire.? We?re now in an integrated marketing communications world, and each medium has a role to play. ?Companies go 100% digital at their peril.
Direct mail, for example, is still an excellent prospecting tool due to the wide availability of highly targeted lists, and the impact of corporate spam filters and the dear old delete key, which reduces the productivity of email for cold prospecting.? Trade shows are making a comeback, with higher quality attendance and happier exhibitors as a result.
Got any B2B marketing myths to add to the list?
Source: http://www.biznology.com/2012/10/b2b-marketing-myth-busting-redux/
pnc Honey Boo Boo yom kippur yom kippur avengers soa andy williams
মঙ্গলবার, ৩০ অক্টোবর, ২০১২
Employers Misclassify Workers to Avoid Workers' Compensation ...
Some employers refuse to play by the rules. What is one way in which employers break the rules and harm our workers? compensation system? Corrupt employers misclassify workers. That is, they incorrectly label employees as independent contractors or outside consultants to avoid important laws related to safety and benefits. This is a disturbing trend which I have previously discussed.
The following is a quote from Leonard Jernigan published on Jon Gelman?s workers? compensation blog that sums up the problem misclassification causes in our workers? compensation system. Both of these attorneys are considered experts in the field of workers? compensation benefits:
When workers are misclassified, insurance companies do not consider them employees. The injured workers are then denied workers? compensation benefits. Additionally, the insurance companies are not paid insurance premiums and are not adequately reserved for the risk of injury by those workers.
When employees are misclassified, everyone suffers. The worker will most likely have his claim for benefits denied. That worker may be able to win his claim but the resulting litigation could prove costly to everyone. Additionally, other employers who followed the law lose because they shoulder the costs of the system. Over the years, I?ve litigated many claims where the employer tried to avoid paying for workers? compensation insurance by misclassifying its employees. Ultimately, we are often able to get these injured workers the benefits to which they were entitled. Unfortunately, the bad acts of these few employers resulted in a lot of pain and expense getting there.
?
?
?
salton sea arizona immigration law aubrey huff the killers julianne hough brandy calvin johnson
Free Food Madness ? From Korea with Love
One of the things my husband and I enjoy every time we shop for groceries in Korea is the free food. If you go to Homeplus or Emart on the weekend, you will find free food in almost every food section, such as mandu (dumpling), ham, sausage, chicken nuggets, noodles, cheese, bread, cereal, fruit,?and would you believe, even samgyupsal and galbi??Drinks like coffee, juice, milk, yogurt drink and other new beverages are also offered to shoppers.
Every time we go to the Philippines and shop for pasalubong (gift), my husband would ask why there aren?t any free food and drinks in the grocery store. This year?s vacation, however, he didn?t need to ask me the same thing, because he FINALLY found a booth in SM Hypermarket that gives free noodles. He was so?excited to?get a freebie?from a?Filipino grocery store for the first time that he actually looked like a four-year old waiting for?the?ice cream man to come. He was the only one in there who seemed interested in getting free noodles, while other shoppers were busy with their shopping. I thought?that scenario was amusing, so I got my camera and took?my husband?s?photo as he was waiting for his noodles. Just then,?one of the staff members approached me and?said that?taking pictures in the grocery store is not allowed. I asked him why. He?told me it?s?their policy in SM. I?wasn?t satisfied with that answer, so I kept probing until the man didn?t know what to say anymore. Hubby got his free noodles and told me to stop torturing the poor staff member.
I got thirsty from?complaining about SM?s policy of ?keeping their grocery store TOP SECRET?, so I was looking for something to drink. Good thing, my husband spotted free coffee. I suddenly remembered Korea where there?s free coffee anywhere you go. We?were each given a paper cup?filled to the brim. That?s the Filipino way of drinking coffee? the cup is always full. In Korea, it?s usually half a?cup.
Hubby liked the coffee, so he bought?a 30-piece pack of the new Kopiko?Astig. If you like strong coffee, like my husband, you may like this flavor, but as for me, Kopiko Brown is still the best instant coffee in the Philippines. ^^
?
My husband and I should have a shopping motto: It?s not the freebie that counts, but the excitement of getting a freebie. ^^
Related articles
Like this:
Be the first to like this.
Posted in Filipino Culture, Filipino Food, Pinas, What I Love about Korea and tagged Business, Coffee, Drink, Food, free coffee, freebie, Grocery store, Kopiko, Korea, Noodle, Philippines, SM HypermarketSource: http://chrissantosra.wordpress.com/2012/10/30/free-food-madness/
judi dench alicia keys bobby brown leaves funeral donnie mcclurkin whitney houston funeral live stream kevin costner whitney houston whitney houston funeral live
Rowdy fans take to streets after Giants' victory
SAN FRANCISCO (AP) ? The city of San Francisco cleaned up Monday after a rowdy World Series celebration turned violent in some neighborhoods and police arrested three dozen people.
The majority of arrests occurred in the Mission District, and included two people on gun charges, police Sgt. Michael Andraychak said.
"There were celebrations all over the city, and they were all peaceful and upbeat," Andraychak said. "Unfortunately, as the night progressed, this other element emerged and were intent on doing violence."
Bonfires of trash were lit in several intersections around the city, and a public transit bus was torched. Windows of several businesses and vehicles were broken, including a news van.
Firefighters needed a police escort to douse a bonfire near the Giants' ball park. They also fought fires fueled by couches, news racks and other debris throughout the city.
Police said a damage report was not yet available.
Mayor Edwin Lee announced a ticker-tape parade would be held at 11 a.m. Wednesday from Market Street to Civic Center Plaza.
A parade after the Giants won the series in 2010 drew hundreds of thousands of fans.
After the game ended Sunday, fans across the city left their televisions and rushed outside, greeting diners, bar patrons and other merrymakers Sunday night after the Giants defeated the Detroit Tigers 4-3 to sweep the Series for their second title in three years.
In the city's Polk Gulch neighborhood, hundreds of fans sprayed champagne, set of off firecrackers and blocked traffic for at least two hours after the game.
Several blocks away, police clad in riot gear looked on as revelers danced around Civic Center plaza where they had watched the game on a Jumbotron.
The thousands of fans assembled at the site exploded in a roar with the final out.
Anthony Yos, 10, hugged his brother Luciano Yos, 15, and the two danced in an embrace with their parents.
"This is the greatest thing," Anthony said with a smile that could go no wider. "The Giants are my favorite team."
Someone in the crowd launched fireworks a few minutes after the game. Strangers hugged strangers, and wine bottles and marijuana cigarettes were shared freely despite a heavy police presence.
"This is San Francisco, "said Laura Chu. "We know how to party."
Sara Vivas brought her 6-year-old daughter Briana Cepeda from Oakland to view the game and join the celebration. They were both clad head-to-toe in Giants garb.
"This is something she will remember forever," Sara said.
Source: http://news.yahoo.com/rowdy-fans-streets-giants-victory-142815641--spt.html
turbo tax katharine mcphee cold mountain valentines day ideas the villages florida egoraptor gisele bundchen
সোমবার, ২৯ অক্টোবর, ২০১২
Mental Health America of Westmoreland County holds awards dinner
(from left), Mental Health America of Westmoreland County Board President, Dr. Paul Niemiec, joins Fred Funari Mental Health America Award of Distinction recipient, John Rusbosin, along with, keynote speaker, Sharon Ward, Executive Director, Pennsylvania Budget and Policy Center, and Mental Health America of Westmoreland County Executive Director, Laurie Barnett Levine, at the Mental Health America of Westmoreland County 49th annual Dinner and Award meeting, held at the Ramada Hotel and Conference Center in Greensburg on Thursday evening, October 25, 2012. Kim Stepinsky | For The Tribune-Review
By Shirley McMarlin
Published: Sunday, October 28, 2012, 9:01?p.m.
Updated 27 minutes ago
The Mental Health America of Westmoreland County 49th Annual Dinner/Award Meeting was held Thursday at the Ramada Hotel and Conference Center east of Greensburg.
The evening?s timely theme was ?Looking Over the Horizon: Health Care Policy in 2013,? which was addressed by keynote speaker Sharon Ward, executive director of the Pennsylvania Budget and Policy Center headquartered in Harrisburg.
Board member Richard Stillwagon introduced the 2012 recipient of the Fred Funari MHA Award of Distinction, named for the former MHAWC president and presented yearly since 1982 for outstanding volunteer service.
Accepting was John Rusbosin of Unity, an area businessman and active participant in a number of community organizations.
Rusbosin was accompanied by wife Jeanne and a contingent representing his large extended family, including Nancy Rusbosin Kelly and John Kelly, Linda Rusbosin James and Tom James, Susie Rusbosin McCormick and Dr. Mark McCormick, Ed and Theresa Rusbosin, Renee Rusbosin Stallings and Janet Rusbosin Barker and Rich Barker.
Representing the Funari family were Josi Funari and Carol Funari Radkowski with Dennis Radkowski.
Also seen: MHAWC Executive Director Laurie Barnett Levine, board president Dr. Paul Niemiec, Vikki Ridenour, Donald Lawry, Molly Robb Shimko and Ken Shimko, Dana Bauer, Dirk Matson, Lynette Emerick, Rose Marie Appel, Kurt Appel and Irma Hutchinson.
Also, Martina Kaufman, Brandy Campbell, John Richert, Pamela Fisher, Phyllis Burton, Linda Parker, Felicia King, Steve and Michelle Penich, Paul and Kathy Plucker and Manny Navarro.
? Shirley McMarlin
You must be signed in to add comments
To comment, click the Sign in or sign up at the very top of this page.
There are currently no comments for this story.
Subscribe today & get the all digital eTRIB! Click here for our subscription offers.lost in space elizabeth banks battle royale key largo arnold palmer invitational ryan madson louisiana primary
Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 29-Oct-2012[ | E-mail |
Share ] Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
PHILADELPHIA New insight into the aggressive behavior of certain adult B-acute lymphoblastic leukemias has provided researchers with a potential new prognostic biomarker and a promising new therapeutic target.
The research, conducted by Ari Melnick, M.D., associate professor of medicine and director of the Raymond and Beverly Sackler Center for Biomedical and Physical Sciences at Weill Cornell Medical College and a hematologist-oncologist at New York-Presbyterian Hospital/Weill Cornell Medical Center, and colleagues, was published in Cancer Discovery, a journal of the American Association for Cancer Research.
Although B-acute lymphoblastic leukemia is highly curable in children, the disease is usually fatal in adults, and researchers have yet to identify why this is the case. Part of the explanation for the poorer outcomes in adults is the higher frequency of genetic alterations associated with unfavorable prognosis.
In order to better understand why these genetic alterations are associated with poor outcomes, Melnick and colleagues studied 215 diagnostic specimens obtained from adults with B-acute lymphoblastic leukemia who were participating in a large Eastern Cooperative Oncology Group phase III clinical trial.
"We performed an integrative epigenomics study to decode the instructions that determine how these cells behave," Melnick said. "The hope was that this would allow us to identify better survival biomarkers and new therapeutic targets."
In many cancers, genetic alterations work in conjunction with epigenetic changes (changes in the way that DNA is modified and packaged) to promote cancerous behaviors. Looking at the B-acute lymphoblastic leukemia specimens, Melnick and colleagues found that many of the leukemias' bad traits were a result of changes in the epigenetic code. In many cases, the epigenetic changes were directly linked to the proteins generated from the genetic alterations and could be used to identify key master regulators required for the leukemic cells to live, according to Melnick.
"For example, we found that a cell surface molecule called CD25 was an extremely powerful indicator of the presence of the most aggressive and fatal cases," Melnick said.
The researchers also discovered that abnormal forms of the E2A and MLL proteins occurring in B-acute lymphoblastic leukemias directly reprogram epigenetic settings at their binding sites throughout the genome.
Most notably, the researchers found that mutant forms of MLL epigenetically reprogramed leukemia cells to express the powerful oncoprotein BCL6, and that BCL6 was required to maintain the proliferation and survival of the leukemia cells.
"We then designed inhibitors of BCL6 and showed that we could kill leukemia cells from patients enrolled in the clinical trial by blocking its function," Melnick said.
Based on these results, the researchers plan to use CD25 as a biomarker to identify those patients who have the worst disease in the next set of clinical trials, and to tailor treatment appropriately. In addition, BCL6 inhibitors are currently being translated for use in humans, and they hope to develop clinical trials targeting BCL6 in MLL-rearranged leukemias.
"These results will ultimately lead to biomarkers that help guide treatment and to the development of therapies that will be more effective for patients with this aggressive form of leukemia," Melnick said.
###
Follow the AACR on Twitter: @aacr #aacr
Follow the AACR on Facebook: http://www.facebook.com/aacr.org
About the American Association for Cancer Research
Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR membership includes more than 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes seven peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the scientific partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of team science and individual grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer.
For more information about the AACR, visit www.AACR.org.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 29-Oct-2012[ | E-mail |
Share ] Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
PHILADELPHIA New insight into the aggressive behavior of certain adult B-acute lymphoblastic leukemias has provided researchers with a potential new prognostic biomarker and a promising new therapeutic target.
The research, conducted by Ari Melnick, M.D., associate professor of medicine and director of the Raymond and Beverly Sackler Center for Biomedical and Physical Sciences at Weill Cornell Medical College and a hematologist-oncologist at New York-Presbyterian Hospital/Weill Cornell Medical Center, and colleagues, was published in Cancer Discovery, a journal of the American Association for Cancer Research.
Although B-acute lymphoblastic leukemia is highly curable in children, the disease is usually fatal in adults, and researchers have yet to identify why this is the case. Part of the explanation for the poorer outcomes in adults is the higher frequency of genetic alterations associated with unfavorable prognosis.
In order to better understand why these genetic alterations are associated with poor outcomes, Melnick and colleagues studied 215 diagnostic specimens obtained from adults with B-acute lymphoblastic leukemia who were participating in a large Eastern Cooperative Oncology Group phase III clinical trial.
"We performed an integrative epigenomics study to decode the instructions that determine how these cells behave," Melnick said. "The hope was that this would allow us to identify better survival biomarkers and new therapeutic targets."
In many cancers, genetic alterations work in conjunction with epigenetic changes (changes in the way that DNA is modified and packaged) to promote cancerous behaviors. Looking at the B-acute lymphoblastic leukemia specimens, Melnick and colleagues found that many of the leukemias' bad traits were a result of changes in the epigenetic code. In many cases, the epigenetic changes were directly linked to the proteins generated from the genetic alterations and could be used to identify key master regulators required for the leukemic cells to live, according to Melnick.
"For example, we found that a cell surface molecule called CD25 was an extremely powerful indicator of the presence of the most aggressive and fatal cases," Melnick said.
The researchers also discovered that abnormal forms of the E2A and MLL proteins occurring in B-acute lymphoblastic leukemias directly reprogram epigenetic settings at their binding sites throughout the genome.
Most notably, the researchers found that mutant forms of MLL epigenetically reprogramed leukemia cells to express the powerful oncoprotein BCL6, and that BCL6 was required to maintain the proliferation and survival of the leukemia cells.
"We then designed inhibitors of BCL6 and showed that we could kill leukemia cells from patients enrolled in the clinical trial by blocking its function," Melnick said.
Based on these results, the researchers plan to use CD25 as a biomarker to identify those patients who have the worst disease in the next set of clinical trials, and to tailor treatment appropriately. In addition, BCL6 inhibitors are currently being translated for use in humans, and they hope to develop clinical trials targeting BCL6 in MLL-rearranged leukemias.
"These results will ultimately lead to biomarkers that help guide treatment and to the development of therapies that will be more effective for patients with this aggressive form of leukemia," Melnick said.
###
Follow the AACR on Twitter: @aacr #aacr
Follow the AACR on Facebook: http://www.facebook.com/aacr.org
About the American Association for Cancer Research
Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR membership includes more than 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes seven peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the scientific partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of team science and individual grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer.
For more information about the AACR, visit www.AACR.org.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-10/aafc-bob102412.php
tiger woods masters 2012 nikki haley stan van gundy navy jet crash virginia beach crash stephen hawking marion barry
Tsunami hits Hawaii after Canada earthquake; first waves smaller than initially feared
HONOLULU (Reuters) - At least 100,000 people in Hawaii were ordered to move from the shoreline to higher ground late on Saturday after a tsunami warning, but the first waves were less forceful than had been feared and no damage was initially reported.
The tsunami, triggered by a powerful earthquake off Canada's Pacific coast, began shortly after 10:30 p.m. Hawaii time, according to the Pacific Tsunami Warning Center, as motorists clogged roadways in a mass exodus from low-lying areas.
"The tsunami arrived about when we expected it should," Senior Geophysicist Gerard Fryer told reporters at a news conference, saying: "I was expecting it to be a little bigger."
The height of the first surge initially was put at 3 feet, but the warning center subsequently reported that early tsunami wave activity peaked at just 2.5 feet at the island of Maui.
There were no immediate reports of serious flooding or damage, but officials warned that additional waves were still possible and that wave heights of up to 6 feet could be reached in some places.
Following the initial surge, Honolulu Mayor Peter Carlisle said it was unclear if the worst had yet passed.
"All of these events are capricious, and you can't really tell which wave is going to be packing the most punch, and sometimes it's the second, third or even the very last one," he told CNN, adding that it might be several hours before officials could give the all-clear and cancel the evacuation.
Tsunami warning sirens in the islands were activated on short notice due to initial confusion among scientists about the quake's undersea epicenter and the extent of the tsunami threat posted by the temblor.
Honolulu Mayor Peter Carlisle announced that all police and emergency personnel were being pulled out from potential flood zones shortly before the first wave, leaving anyone defying evacuation orders to fend for themselves. He urged motorists who remained caught in harm's way due to gridlocked roads to abandon their vehicles and proceed on foot.
"If you are stuck in traffic, you might consider getting out of your car and consider walking to higher ground. You will have to assess your own situation, depending on where you are right now. Right now it is critical," he said
Vindell Hsu, a geophysicist at the Tsunami Warning Center said an estimated 100,000 to 150,000 people who live in Hawaii's coastal zones had been urged to move to higher ground until after 10:30 p.m.
Governor Neil Abercrombie issued an emergency proclamation for the state.
The tsunami center cautioned that wave height could not be predicted and that the first wave "may not be the largest".
It said: "All shores are at risk no matter which direction they face".
CANADA QUAKE
The warnings followed a powerful earthquake with a magnitude of 7.7 that hit Canada's Pacific coastal province of British Columbia late on Saturday [ID:nL1E8LS03H].
The U.S. Geological Survey said the quake was centered 123 miles south-southwest of Prince Rupert at a depth of 6.2 miles.
The Earthquakes Canada agency said the quake was followed by numerous aftershocks as large as magnitude 4.6 and that a small tsunami has been recorded by a deep-ocean pressure sensor.
On Oahu, Hawaii's most populous island, tsunami warning sirens could be heard blaring out across Honolulu, the state capital, prompting an immediate crush of traffic, with many motorists stopping at service stations to top up with gasoline. At movie theaters, films were halted in mid-screening as announcements were made urging patrons to return to their homes.
The last time Oahu had a tsunami warning was after the devastating Japanese earthquake of March 2011.
On Honolulu's famed Waikiki Beach, residents of high-rise buildings were told to move to the third floor or higher for safety.
Stephany Sofos, a resident of Diamond Head near Waikiki, said most people had either evacuated or relocated to a higher floor.
"I moved my car up the hill, packed up my computer and have my animals all packed and with me," Sofos said, saying that she had not yet seen any obvious receding of the surf, a telltale sign that a tsunami wave is imminent.
"I'm pretty confident because we have a lot of reefs out there and that will prevent any major damage. Maybe it's a false confidence, but I'm not really worried," she said, adding, "It is nerve-wracking."
Tsunami Warning Center Geophysicist Gerard Fryer said the tsunami had caught scientists by surprise.
"We thought that the earthquake was on land and when we learned that it was deeper undersea and we gathered more information, we had no choice but to issue a warning," he said
As residents scrambled to reach higher ground on Oahu, at least four major road accidents were reported by the state Emergency Medical Services. More accidents were also reported on the outer islands.
A tsunami advisory was also posted for coastal areas of northern California and Oregon, where a maximum sea level rise was estimated at 6 inches, the National Weather Service said. The agency said no significant flooding was expected.
(Reporting by Jorene Barut and Suzanne Roig in Honolulu; Writing by Steve Gorman and Tim Gaynor; Editing by Andrew Osborn)
Source: http://news.yahoo.com/tsunami-warning-issued-hawaii-british-columbia-quake-072144007.html
protect ip act jim caldwell internet blackout jessica capshaw seattle times seattle times walker recall
British media: Rocker Gary Glitter arrested in connection with Savile case
LONDON - Police investigating the sex abuse scandal surrounding late BBC children's television host Jimmy Savile have arrested pop star Gary Glitter in connection with the case, British media said Sunday.
Metropolitan Police said they arrested a man in his 60s early Sunday morning at his London home, on suspicion of sexual offences, and that he remains in custody in a London police station.
The force did not identify the man, but British media including the BBC and Press Association reported he was Glitter, 68, a former rock musician and a convicted sex offender. Glitter's real name is Paul Gadd.
Hundreds of potential victims have come forward since police began their investigation into sex abuse allegations against Savile, the longtime host of popular shows "Top of the Pops" and "Jim'll Fix It" who died at age 84 last year. Most allege abuse by Savile, but some said they were abused by Savile and others.
Glitter, best known for "Rock & Roll (Part 1&2)," was convicted in 2006 in Vietnam of committing "obscene acts with children" ? offences involving girls aged 10 and 11. He was deported in 2008.
He had a previous conviction in Britain for possessing child pornography.
The scandal has horrified Britain with revelations that Savile cajoled and coerced vulnerable teens into having sex with him in his car, in his camper van, and even in dingy dressing rooms on BBC premises.
Police have said that though the majority of cases related to Savile alone, some involved the entertainer and other, unidentified suspects. In addition, some potential victims who reported abuse by Savile also told police about separate allegations against unidentified men that did not involve the BBC host.
Source: http://news.yahoo.com/rocker-gary-glitter-arrested-connection-savile-case-british-111304759.html
ok go peyton manning super bowl nsx chad ochocinco roman numerals new england patriots madonna
Brane Space: Are Online Colleges the Solution? Arguably, NO!
Left: First year Philosophy students at Loyola Universtiy, ca. 1965. There is no way they could have received the quality education they did from any "online" or secondary educational outlet
In a recent TIME article, 'Reinventing College', online?colleges-universities, including in the form of?offering 'MOOCs' (massive open online courses)?or as scaled-down for-profits offering outright credits (such as Udacity) have been bandied about as a solution to two major problems inherent in U.S. tertiary education:
1) The massive college debt accrued by graduates, now estimated at over $900 billion and which undermines their economic viability in a nation with few high paying decent jobs, and
2) The fact the U.S.?now lags behind major competitors in terms of numbers of people in the workforce with college degrees. (The U.S. has currently 54 million compared to 127 million in India and 161 million in the OECD nations.
Another sobering fact takeaway from the piece: despite all the massive college debt "three semesters of college have produced a barely noticeable impact on critical thinking, complex reasoning? and writing skills" - according to a 2011 book, 'Academically Adrift'.
This is very serious indeed, because in today's multi-faceted economic and scientific?world - where many complex issues bear on the electorate, from Keynesian?stimulus advantage, to supply side nonsense, to the concept of 'aggregate demand', not to mention global warming-climate change and the consumption of fossil fuels beyond the practical EROEI?(energy returned on energy invested) limit, we absolutely must have intelligent and well educated people to be able to process the information and make informed decisions.?This often requires not only critical thinking and complex reasoning abilities but the knowledge by which to parse and sort out the competing claims.?One therefore must be practiced in the application of critical thinking and complex reasoning to actual scientific and economic questions.
I maintain, despite all the hoopla about?college "options" (i.e. replacing the formal college degree with one from an online venue) that there is no substitute for partaking in the actual, physical college environment. ??Now, this is not to say some benefit can't arrive via Moocs, e.g. such as at MIT:
http://ocw.mit.edu/courses/audio-video-courses/
and Yale University:
http://oyc.yale.edu/
However, ?intensive education toward a degree must be necessarily bound up with brick and mortar institutions. Why? Let me priovide several reasons:
1) Accreditation:
This is the sine qua non indicator for quality assurance. Given thousands of schools, universities, colleges, there must be some way - some standard - by which they can be judged, at least at the minimal level. Accreditation provides this. Hence, any degree-offering online substitute must at least be accredited by an outside entity of value itself. Else, its degree means nothing and won't to any prospective employer either.
What official body has accredited the institution of higher learning? There are six major accrediting bodies in the United States. In the case of the Southern U.S. (and for Loyola) the accrediting body is the Commission on Colleges of the Southern Association of Colleges and Schools.
2) Advantage of learning one-to-one (tutorials):
This is critical and maybe one of the most crucial components but may not be present (for obvious reasons) in distant learning. For example, this means when a student encounters a difficult impasse, as he or she surely will, he can meet one-to-one with a professor and hash out the difficulty. At Loyola, for example, professors were always available and also conducted tutorials (weekly meetings with only a few students for problem solving or question resolution purposes. )
When I taught? Space Physics (including labs)?at the University of Alaska-Fairbanks, I always set aside office hours to meet one- on- one with students having difficulties. I did the same when I taught at Harrison College (physics, math) in Barbados. Students often told me after the semester that these sessions meant more than the regular classroom contacts because they were more directly challenged to show their ability at more fundamental, as well as critical thinking levels.
Those office hours often meant the difference between a student doing well on a class project, or not. Or more critically, passing the course, or failing it. A student- I don't care how diligent he is, simply can't obtain the same measure of mastery without that intense contact which is directed to the sole purpose of resolving the difficulty. It simply isn't the same as staring at a passive computer monitor - or even an online tutorial or physics class when you can't get answers to questions or immediate feedback at that instant. (From the TIME author's piece, you can at Udacity, but it is kind of a 'cut and paste' homogeneous operation. For example, one of Udacity's general physics instructors - an Andy Brown - while he can toss out assorted questions every few minutes (the average college student's attention span is said to be 9-12 mins. before drifting), he cannot give you assorted lab materials and have you design your own experiment to measure the acceleration of gravity, g, on the spot!)
3) Development of Writing Skills:
Back in the 'day' - before the arrival of the egregious 'teacher evaluation forms' and hence the blackmail of profs to get unearned high grades, in-depth writing was part of nearly all courses, from physics to philosophy. Today, because of time constraints or whatever...that's almost entirely vanished. Very few college students are asked to write comprehensive (e.g. for homework) ?essays such as we were at Loyola (in philosophy, English?and theology) or engage in displaying the sort of complex reasoning, say in physics, as I've regularly?demanded of?my students in physics, or space physics. 'Writing' then, is regarded as mostly a marginal or side issue today, when in fact it is the core demonstration of thought, including advanced thought. If a student can't write, one can make the claim he can't think - or at least cogently and clearly express his thoughts, which amounts to the same thing.
Most college students today, according to assorted surveys, claim an average of 15 minutes of writing per nightly homework, compared to nearly 2?? hours back in the 1960s. However, and this is important, not even that 15 minute threshold is met by the online for profit outfits like Udacity - which seem to prefer short form answer, on-the-spot questions, responses. (The TIME writer never mentioned any advanced writing exercises, say in Andy Brown's Udacity physics class, along the lines of comparing Newtonian gravitational theory with Einsteinian general relativity, or how Newton's law of gravitation helped to refine Kepler's laws of planetary motion).
4) Socialization aspect and learning interactively as a group:
In?the Loyola first year?philosophy class (see image shown) we actually learned from each other. Using the "Socratic Method" (made famous by the character known as "Professor Kingsfield" in the series Paper Chase) our prof, Fr.Hecker , would press and probe students one by one to elicit the optimum answers and insights in exploring whatever aspect came up. Thus, as one student answered the question (and thereby introduced a new question for another) we referenced our own resolution by way of his or her answer. As the process continued, each new question?pursued more deeply by?Fr. Hecker , we assimilated it for?further study, reference. This dynamic interplay is not possible when a single student tries to master a difficult subject via long distance access only. One way I could describe it is the class experience is three dimensional but the distance learner's is at most two dimensional.
Sure there are many advantages to distance learning, such as saving gas and time, as well as not having to expose oneself to thousands of people with different ideas (that you may not like) but the total college experience is to me, what makes it unique - and which one can't just obtain from online learning.
Lastly, there is the key issue of what is college for? As I've intimated many times before, I do not believe one can adopt a strictly utilitarian stance and absolutely expect you will land a high profile job, no matter how many tens of thousands you've shelled out. I am not alone in this!? In his own perceptive take ('The Myth of Higher Education') Dr. Stephen Mason in an issue of Integra the journal of Intertel,?argued cogently?that a huge error of American education is orientating it explicitly for the utilitarian purpose of making money or getting a job.
?As he points out, this is terribly short-sighted, and what if after enormous expense no remunerative job is forthcoming? (A serious possibility in today's world where even high tech computer and engineering jobs are being dispatched to India thanks to GE and Cisco). It therefore is extremely parlous and presumptive for a person to expend an enormous amount on either a standard 'brick and mortar' university education or an online -distant learning one, if the sole objective is to earn a living based on one's degree. In Mason's take(op. cit.):
?"the bottom line regarding a well -rounded education is that it has nothing to do with any kind of bottom line. Its value (non-monetary) is to be found in the quality it adds to one's life. It allows one to better appreciate music, art, history and literature. It contributes to a better understanding of language and culture, nature and philosophy. It expands rather than limits horizons and replaces faith and belief with reason and logic."
Mason adds that it "teaches a person to live - not to earn a living" and that living encompasses an impetus for further learning just for its own sake. If a fantastic, well-paying job also comes with it, that's icing on the cake. Fortunately, when I attended Loyola University (1964-67), the whole thrust was about two things: 1) critical thinking (now tested regularly on the Graduate Record Exam which must normally be taken before one undertakes post-graduate education) and 2) open inquiry that motivates further learning.
I have found both of these immensely crucial and useful in parsing today's complex political environment, which is why I also blog so often about poltical issues with complex?subtexts?- in the interests of sharing. I only wish more of our citizens would or could possess these same advantages in the interests of making fewer parlous electoral errors - which in the long run exact a terrible cost on our nation.
As for the online courses offered, such as those at Yale and MIT, I believe most would agree with me that they are best used for 'continuing education' of already degreed citizens. Learning in this sense ought not cease with a piece of paper or parchment but be continuous until one ceases to breathe .....or loses cognitive functions. If more Americans also agreed with this, we might see a much more intelligent, informed electorate .....as opposed to voters (according to a UCLA political sci. prof on Chris Hayes' 'UP' this morning) who identify with Mitt Romney and his "values" whether he acts as the savage Rightist Plutocrat, or the phoney baloney "moderate".
Source: http://brane-space.blogspot.com/2012/10/are-online-colleges-solution-arguably-no.html
army wives 60 minutes go daddy tim tebow Tom Kenny Long Island Medium Alfonso Ribeiro
এতে সদস্যতা:
মন্তব্যসমূহ (Atom)